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- W1973138001 abstract "We have shown that systemic administration of interleukin-1β (IL-1β) excites gastric vagal afferent activity in part via stimulation of type A cholecystokinin (CCK-A) receptors in rats. The present study was undertaken to determine whether the response of the gastric vagal afferent nerve to systemic IL-1β is altered in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which lack CCK-A receptors. The response was compared with that of the control strain, Long-Evans Tokushima Otsuka (LETO) rats. All animals were anesthetized with pentobarbital and artificially ventilated. Intravenous administration of 4 μg/kg of IL-1β increased gastric vagal afferent activity in both LETO and OLETF rats, whereas a smaller dose of 2 μg/kg of IL-1β increased activity only in the OLETF rats. The present results demonstrate that the response of the gastric vagal afferent activity in CCK-A receptor deficient OLETF rats was more sensitive to intravenous administration of IL-1β than was in control LETO rats." @default.
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- W1973138001 date "2000-10-01" @default.
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- W1973138001 title "Effects of systemic injection of interleukin-1β on gastric vagal afferent activity in rats lacking type A cholecystokinin receptors" @default.
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- W1973138001 doi "https://doi.org/10.1016/s0304-3940(00)01479-8" @default.
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