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• W1973144649 abstract "FK506-binding protein 12 (FKBP12) is an evolutionarily conserved immunophilin that binds the immunosuppressants FK506 and rapamycin. The physiological roles of this protein, however, remain unclear. The possible function of FKBP12 in embryonic development was investigated by examining the distribution of FKBP12 mRNA in chick embryos by whole-mount in situ hybridization. The FKBP12 transcripts were detected at early stages of embryonic development, being especially abundant in the somites, heart tube and nervous system. Transcripts were also enriched in the neural fold, especially at the edge of this structure. Treatment of early embryos with rapamycin resulted in failure of neural tube closure, whereas treatment with FK506 had no such effect, suggesting that the FKBP12–rapamycin complex interferes with the formation of the neural tube. Given that rapamycin inhibits mitogenic signaling pathways, the FKBP12–rapamycin complex might disrupt mitosis during the formation of the neural tube. The lack of effect of FK506 on neural tube formation suggests that calcineurin signaling does not contribute to the formation of this structure during chick embryogenesis." @default.
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• W1973144649 date "2002-06-01" @default.
• W1973144649 modified "2023-09-27" @default.
• W1973144649 title "Effects of FK506 and rapamycin on formation of the neural tube in chick embryos" @default.
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• W1973144649 doi "https://doi.org/10.1046/j.1344-3941.2002.00032.x" @default.
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