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• W1973159670 abstract "The tight-binding I12-X86 lac repressor binds to non-operator DNA in a sequence-specific fashion. Using the DNA of the E. coli I gene we have investigated these sequence-specific interactions and compared them to the operator binding of wild-type repressor. The specific, non-operator DNA interactions are sensitive to the inducer IPTG. One strong binding site in the I gene DNA was found to be one of two expected on the basis of their homology with the lac operator. The binding of I12-X86 repressor to this site was visualized using the footprinting technique, and found to be consistent with an operator-like binding configuration. The protection pattern extends into an adjacent sequence suggesting that two repressor tetramers are bound in tandem." @default.
• W1973159670 created "2016-06-24" @default.
• W1973159670 creator A5015807290 @default.
• W1973159670 creator A5055985023 @default.
• W1973159670 date "1980-01-01" @default.
• W1973159670 modified "2023-09-23" @default.
• W1973159670 title "Sequence-specific interactions of the tight-binding I12-X86 lac repressor with non-operator DNA" @default.
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• W1973159670 doi "https://doi.org/10.1093/nar/8.3.487" @default.
• W1973159670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/327285" @default.
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