Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973160597> ?p ?o ?g. }
- W1973160597 endingPage "358" @default.
- W1973160597 startingPage "351" @default.
- W1973160597 abstract "Exposure to high levels of manganese (Mn) is known to produce a complex neurological syndrome with psychiatric disturbances, cognitive impairment, and parkinsonian features. However, the neurobiological basis of chronic low-level Mn exposure is not well defined. We now provide evidence that exposure to levels of Mn that results in blood Mn concentrations in the upper range of environmental and occupational exposures and in certain medical conditions produces widespread Mn accumulation in the nonhuman primate brain as visualized by T1-weighted magnetic resonance imaging. Analysis of regional brain Mn distribution using a “pallidal index equivalent” indicates that this approach is not sensitive to changing levels of brain Mn measured in postmortem tissue. Evaluation of longitudinal 1H-magnetic resonance spectroscopy data revealed a significant decrease (p = 0.028) in the N-acetylaspartate (NAA)/creatine (Cr) ratio in the parietal cortex and a near significant decrease (p = 0.055) in frontal white matter (WM) at the end of the Mn exposure period relative to baseline. Choline/Cr or myo-Inositol/Cr ratios did not change at any time during Mn exposure. This indicates that the changes in the NAA/Cr ratio in the parietal cortex are not due to changes in Cr but in NAA levels. In summary, these findings suggest that during chronic Mn exposure a significant amount of the metal accumulates not only in the basal ganglia but also in WM and in cortical structures where it is likely to produce toxic effects. This is supported by a significantly decreased, in the parietal cortex, NAA/Cr ratio suggestive of ongoing neuronal degeneration or dysfunction." @default.
- W1973160597 created "2016-06-24" @default.
- W1973160597 creator A5000733151 @default.
- W1973160597 creator A5012087640 @default.
- W1973160597 creator A5021181636 @default.
- W1973160597 creator A5032058505 @default.
- W1973160597 creator A5061860571 @default.
- W1973160597 creator A5084458781 @default.
- W1973160597 creator A5086927415 @default.
- W1973160597 date "2006-07-31" @default.
- W1973160597 modified "2023-10-17" @default.
- W1973160597 title "Evidence for Cortical Dysfunction and Widespread Manganese Accumulation in the Nonhuman Primate Brain following Chronic Manganese Exposure: A 1H-MRS and MRI Study" @default.
- W1973160597 cites W143802866 @default.
- W1973160597 cites W1509839138 @default.
- W1973160597 cites W1965302622 @default.
- W1973160597 cites W1977925895 @default.
- W1973160597 cites W1978165184 @default.
- W1973160597 cites W1987114126 @default.
- W1973160597 cites W1990083304 @default.
- W1973160597 cites W2001567949 @default.
- W1973160597 cites W2002562482 @default.
- W1973160597 cites W2004196774 @default.
- W1973160597 cites W2008988556 @default.
- W1973160597 cites W2016996792 @default.
- W1973160597 cites W2018907336 @default.
- W1973160597 cites W2028087399 @default.
- W1973160597 cites W2033516005 @default.
- W1973160597 cites W2033579584 @default.
- W1973160597 cites W2039413275 @default.
- W1973160597 cites W2041066813 @default.
- W1973160597 cites W2052766882 @default.
- W1973160597 cites W2053868891 @default.
- W1973160597 cites W2058458909 @default.
- W1973160597 cites W2061847197 @default.
- W1973160597 cites W2066753016 @default.
- W1973160597 cites W2067620208 @default.
- W1973160597 cites W2074924623 @default.
- W1973160597 cites W2078284982 @default.
- W1973160597 cites W2082254529 @default.
- W1973160597 cites W2091850152 @default.
- W1973160597 cites W2095750277 @default.
- W1973160597 cites W2120043043 @default.
- W1973160597 cites W2123510007 @default.
- W1973160597 cites W2123817334 @default.
- W1973160597 cites W2130915126 @default.
- W1973160597 cites W2140343406 @default.
- W1973160597 cites W2145331030 @default.
- W1973160597 cites W2146738194 @default.
- W1973160597 cites W2149370666 @default.
- W1973160597 cites W2152014584 @default.
- W1973160597 cites W2158249096 @default.
- W1973160597 cites W2284154440 @default.
- W1973160597 cites W2317606957 @default.
- W1973160597 cites W2443046798 @default.
- W1973160597 cites W38866710 @default.
- W1973160597 cites W77541376 @default.
- W1973160597 doi "https://doi.org/10.1093/toxsci/kfl106" @default.
- W1973160597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16968886" @default.
- W1973160597 hasPublicationYear "2006" @default.
- W1973160597 type Work @default.
- W1973160597 sameAs 1973160597 @default.
- W1973160597 citedByCount "102" @default.
- W1973160597 countsByYear W19731605972012 @default.
- W1973160597 countsByYear W19731605972013 @default.
- W1973160597 countsByYear W19731605972014 @default.
- W1973160597 countsByYear W19731605972015 @default.
- W1973160597 countsByYear W19731605972016 @default.
- W1973160597 countsByYear W19731605972017 @default.
- W1973160597 countsByYear W19731605972018 @default.
- W1973160597 countsByYear W19731605972019 @default.
- W1973160597 countsByYear W19731605972020 @default.
- W1973160597 countsByYear W19731605972021 @default.
- W1973160597 countsByYear W19731605972022 @default.
- W1973160597 countsByYear W19731605972023 @default.
- W1973160597 crossrefType "journal-article" @default.
- W1973160597 hasAuthorship W1973160597A5000733151 @default.
- W1973160597 hasAuthorship W1973160597A5012087640 @default.
- W1973160597 hasAuthorship W1973160597A5021181636 @default.
- W1973160597 hasAuthorship W1973160597A5032058505 @default.
- W1973160597 hasAuthorship W1973160597A5061860571 @default.
- W1973160597 hasAuthorship W1973160597A5084458781 @default.
- W1973160597 hasAuthorship W1973160597A5086927415 @default.
- W1973160597 hasBestOaLocation W19731605971 @default.
- W1973160597 hasConcept C126322002 @default.
- W1973160597 hasConcept C126838900 @default.
- W1973160597 hasConcept C134018914 @default.
- W1973160597 hasConcept C143409427 @default.
- W1973160597 hasConcept C15744967 @default.
- W1973160597 hasConcept C169760540 @default.
- W1973160597 hasConcept C185592680 @default.
- W1973160597 hasConcept C2777348757 @default.
- W1973160597 hasConcept C2778187257 @default.
- W1973160597 hasConcept C2779896295 @default.
- W1973160597 hasConcept C2781041448 @default.
- W1973160597 hasConcept C2781123555 @default.
- W1973160597 hasConcept C2781192897 @default.
- W1973160597 hasConcept C529278444 @default.
- W1973160597 hasConcept C6757342 @default.