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• W197316475 abstract "Research Article1 November 1993free access Yeast syntaxins Sso1p and Sso2p belong to a family of related membrane proteins that function in vesicular transport. M.K. Aalto M.K. Aalto VTT Biotechnical Laboratory, Espoo, Finland. Search for more papers by this author H. Ronne H. Ronne VTT Biotechnical Laboratory, Espoo, Finland. Search for more papers by this author S. Keränen S. Keränen VTT Biotechnical Laboratory, Espoo, Finland. Search for more papers by this author M.K. Aalto M.K. Aalto VTT Biotechnical Laboratory, Espoo, Finland. Search for more papers by this author H. Ronne H. Ronne VTT Biotechnical Laboratory, Espoo, Finland. Search for more papers by this author S. Keränen S. Keränen VTT Biotechnical Laboratory, Espoo, Finland. Search for more papers by this author Author Information M.K. Aalto1, H. Ronne1 and S. Keränen1 1VTT Biotechnical Laboratory, Espoo, Finland. The EMBO Journal (1993)12:4095-4104https://doi.org/10.1002/j.1460-2075.1993.tb06093.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The yeast SEC1 gene encodes a hydrophilic protein that functions at the terminal stage in secretion. We have cloned two yeast genes, SSO1 and SSO2, which in high copy number can suppress sec1 mutations and also mutations in several other late acting SEC genes, such as SEC3, SEC5, SEC9 and SEC15. SSO1 and SSO2 encode small proteins with N-terminal hydrophilic domains and C-terminal hydrophobic tails. The two proteins are 72% identical in sequence and together perform an essential function late in secretion. Sso1p and Sso2p show significant sequence similarity to six other proteins. Two of these, Sed5p and Pep12p, are yeast proteins that function in transport from ER to Golgi and from Golgi to the vacuole, respectively. Also related to Sso1p and Sso2p are three mammalian proteins: epimorphin, syntaxin A/HPC-1 and syntaxin B. A nematode cDNA product also belongs to the new protein family. The new protein family is thus present in a wide variety of eukaryotic cells, where its members function at different stages in vesicular transport. Previous ArticleNext Article Volume 12Issue 111 November 1993In this issue RelatedDetailsLoading ..." @default.
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• W197316475 date "1993-11-01" @default.
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• W197316475 title "Yeast syntaxins Sso1p and Sso2p belong to a family of related membrane proteins that function in vesicular transport." @default.
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• W197316475 doi "https://doi.org/10.1002/j.1460-2075.1993.tb06093.x" @default.
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