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- W1973165989 abstract "These investigations performed in dogs extend previous observations on the inhibition of insulin secretion by epinephrine and diazoxide. Epinephrine and diazoxide, each and in combination, suppressed plasma IRI concentrations, but only diazoxide inhibition of plasma IRI was reversed by tolbutamide. Tolbutamide administration to dogs receiving diazoxide and glucose resulted in a twofold increase in plasma IRI over the steady-state value prior to diazoxide administration, whereas tolbutamide administered to dogs receiving glucose alone did not result in any further increase in plasma IRI. The plasma insulin hyperresponsiveness to tolbutamide in the diazoxide-treated animals was completely blocked by beta adrenergic blockade with propranolol, a finding not explained by differences in blood glucose. Hyperresponsiveness to tolbutamide was not observed if diazoxide had been administered for less than 15 min prior to tolbutamide. The hyperresponsiveness to tolbutamide in diazoxide-treated animals probably cannot be attributed solely to increased insulin accumulation in the pancreas during diazoxide treatment but might be explained by accumulation of some metabolite or accentuation of some enzyme activity in the beta cell during prolonged diazoxide administration. Inhibition of the hyperresponsiveness to tolbutamide by beta adrenergic blockade is compatible with the hypothesis that cAMP accumulation might be responsible for the increased plasma insulin response." @default.
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- W1973165989 date "1971-11-01" @default.
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- W1973165989 title "Hyperresponsiveness to tolbutamide of dogs pretreated with diazoxide" @default.
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- W1973165989 doi "https://doi.org/10.1016/0026-0495(71)90025-4" @default.
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