FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973170537> ?p ?o ?g. }

• W1973170537 endingPage "31" @default.
• W1973170537 startingPage "23" @default.
• W1973170537 abstract "The purpose of this study was to investigate the effects of Tityus serrulatus venom (TSV) on murine peritoneal macrophages evaluated in terms of activation. The effects of crude TSV were analysed by detection of cytokines, oxygen intermediate metabolites (H 2 O 2 ) and nitric oxide (NO) in supernatants of peritoneal macrophages. Several functional bioassays were employed including an in vitro model for envenomating: cytotoxicity of TSV was assessed using the lyses percentage. Tumor necrosis factor (TNF) activity was assayed by measuring its cytotoxic activity on L-929 cells, and interleukin-6 (IL-6) and interferon-γ (IFN-γ) were assayed by enzyme-linked immunosorbent assay, whereas NO levels were detected by Griess colorimetric reactions in culture supernatant of macrophages incubated with TSV and subsequently exposed to either lipopolysaccharide or IFN-γ. Incubation of macrophages with TSV increased production of IL-6 and IFN-γ in a dose-dependent manner. TNF production was not detected in supernatants treated with TSV at any concentration. The increase in IL-6 secretion was not associated with concentration-dependent cytoxicity of TSV on these cells. These data suggest that the cytotoxicity does not appear to be the main cause of an increased cytokine production by these cells. Although NO is an important effector molecule in macrophage microbicidal activity, the inducing potential of the test compounds for its release was found to be very moderate, ranging from 125 to 800 mM. Interestingly, NO levels of peritoneal macrophages were increased after IFN-γ. Moreover, NO production had an apparent effect on macrophage activity. The results obtained here also shown that the TSV induces an important elevation in H 2 O 2 release. These results combined with NO production suggest that TSV possesses significant immunomodulatory activities capable of stimulating immune functions in vitro ." @default.
• W1973170537 created "2016-06-24" @default.
• W1973170537 creator A5040893228 @default.
• W1973170537 date "2002-01-01" @default.
• W1973170537 modified "2023-09-29" @default.
• W1973170537 title "Effect of<i>Tityus serrulatus</i>venom on cytokine production and the activity of murine macrophages" @default.
• W1973170537 cites W140601849 @default.
• W1973170537 cites W1551592047 @default.
• W1973170537 cites W1572295857 @default.
• W1973170537 cites W1633041824 @default.
• W1973170537 cites W1856702249 @default.
• W1973170537 cites W1963492254 @default.
• W1973170537 cites W1968876368 @default.
• W1973170537 cites W1970388960 @default.
• W1973170537 cites W1973018387 @default.
• W1973170537 cites W1973453969 @default.
• W1973170537 cites W1973975275 @default.
• W1973170537 cites W1980482622 @default.
• W1973170537 cites W1987899402 @default.
• W1973170537 cites W2013340592 @default.
• W1973170537 cites W2013824064 @default.
• W1973170537 cites W2018931269 @default.
• W1973170537 cites W2019814232 @default.
• W1973170537 cites W2023406821 @default.
• W1973170537 cites W2029432146 @default.
• W1973170537 cites W2071566549 @default.
• W1973170537 cites W2072344266 @default.
• W1973170537 cites W2072668724 @default.
• W1973170537 cites W2073132923 @default.
• W1973170537 cites W2082361351 @default.
• W1973170537 cites W2084129051 @default.
• W1973170537 cites W2133354596 @default.
• W1973170537 cites W2139535814 @default.
• W1973170537 cites W2164392688 @default.
• W1973170537 cites W2172466148 @default.
• W1973170537 cites W2177385981 @default.
• W1973170537 doi "https://doi.org/10.1080/09629350210308" @default.
• W1973170537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1781641" @default.
• W1973170537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11926592" @default.
• W1973170537 hasPublicationYear "2002" @default.
• W1973170537 type Work @default.
• W1973170537 sameAs 1973170537 @default.
• W1973170537 citedByCount "35" @default.
• W1973170537 countsByYear W19731705372013 @default.
• W1973170537 countsByYear W19731705372014 @default.
• W1973170537 countsByYear W19731705372015 @default.
• W1973170537 countsByYear W19731705372016 @default.
• W1973170537 countsByYear W19731705372017 @default.
• W1973170537 countsByYear W19731705372018 @default.
• W1973170537 countsByYear W19731705372019 @default.
• W1973170537 countsByYear W19731705372021 @default.
• W1973170537 countsByYear W19731705372022 @default.
• W1973170537 crossrefType "journal-article" @default.
• W1973170537 hasAuthorship W1973170537A5040893228 @default.
• W1973170537 hasBestOaLocation W19731705371 @default.
• W1973170537 hasConcept C109316439 @default.
• W1973170537 hasConcept C134018914 @default.
• W1973170537 hasConcept C153911025 @default.
• W1973170537 hasConcept C154317977 @default.
• W1973170537 hasConcept C17991360 @default.
• W1973170537 hasConcept C185592680 @default.
• W1973170537 hasConcept C202751555 @default.
• W1973170537 hasConcept C203014093 @default.
• W1973170537 hasConcept C2778690821 @default.
• W1973170537 hasConcept C2778754761 @default.
• W1973170537 hasConcept C2779244956 @default.
• W1973170537 hasConcept C2779448229 @default.
• W1973170537 hasConcept C519581460 @default.
• W1973170537 hasConcept C55493867 @default.
• W1973170537 hasConcept C86803240 @default.
• W1973170537 hasConcept C98274493 @default.
• W1973170537 hasConceptScore W1973170537C109316439 @default.
• W1973170537 hasConceptScore W1973170537C134018914 @default.
• W1973170537 hasConceptScore W1973170537C153911025 @default.
• W1973170537 hasConceptScore W1973170537C154317977 @default.
• W1973170537 hasConceptScore W1973170537C17991360 @default.
• W1973170537 hasConceptScore W1973170537C185592680 @default.
• W1973170537 hasConceptScore W1973170537C202751555 @default.
• W1973170537 hasConceptScore W1973170537C203014093 @default.
• W1973170537 hasConceptScore W1973170537C2778690821 @default.
• W1973170537 hasConceptScore W1973170537C2778754761 @default.
• W1973170537 hasConceptScore W1973170537C2779244956 @default.
• W1973170537 hasConceptScore W1973170537C2779448229 @default.
• W1973170537 hasConceptScore W1973170537C519581460 @default.
• W1973170537 hasConceptScore W1973170537C55493867 @default.
• W1973170537 hasConceptScore W1973170537C86803240 @default.
• W1973170537 hasConceptScore W1973170537C98274493 @default.
• W1973170537 hasIssue "1" @default.
• W1973170537 hasLocation W19731705371 @default.
• W1973170537 hasLocation W19731705372 @default.
• W1973170537 hasLocation W19731705373 @default.
• W1973170537 hasLocation W19731705374 @default.
• W1973170537 hasOpenAccess W1973170537 @default.
• W1973170537 hasPrimaryLocation W19731705371 @default.
• W1973170537 hasRelatedWork W1500704576 @default.
• W1973170537 hasRelatedWork W1871445714 @default.
• W1973170537 hasRelatedWork W1973170537 @default.
• W1973170537 hasRelatedWork W1990434843 @default.

• next