Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973171307> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1973171307 endingPage "665" @default.
- W1973171307 startingPage "659" @default.
- W1973171307 abstract "Objectives Recent recommendations suggest that sodium bicarbonate may not be useful for the treatment of metabolic acidosis. However, these recommendations are based primarily on both clinical studies and animal models of metabolic acidosis with arterial hypoxemia (Pao2 of < 80 torr [<10.7 kPa]). This study was designed to determine the safety and physiologic effects of low-dose sodium bicarbonate in humans who developed intraoperative metabolic acidosis in the absence of hypoxemia. Design Prospective, double-blind, randomized trial. Setting Veterans Affairs Medical Center (a teaching hospital of the University of California, San Francisco). Patients We prospectively studied 40 patients with coronary artery disease who underwent major surgery and developed mild intraoperative metabolic acidosis (decrease of plasma bicarbonate by >3 mM). Interventions Patients were randomly assigned to receive either sodium bicarbonate (n = 20) or sodium chloride (n = 20) by intravenous bolus, up to a maximum dose of 88 mmol of sodium. Measurements and Main Results Bicarbonate treatment significantly increased the mean arterial pH from 7.36 to 7.39; the mean serum bicarbonate concentration from 21 to 25 mmol/L; and Pco2 from 41 to 44 torr (5.5 to 5.9 kPa). Total body oxygen consumption and lactate production did not change. Similarly, no adverse changes occurred in systemic or pulmonary arterial pressures or in cardiac ejection fraction. After bicarbonate administration, both the cardiac output and systemic oxygen consumption decreased by 8% to 11%, while both variables increased by 13% after sodium chloride administration; but, none of the changes was significant. One patient in the bicarbonate group developed myocardial ischemia, compared with three patients in the saline group. Conclusions Administration of sodium bicarbonate to well-oxygenated patients with mild metabolic acidosis resulted in a correction of the acidosis, without significant changes in cardiac output, total body oxygen use, or Pao2 (oxygen tension). These effects remain to be validated in patients with hypoxemia, more severe acidosis, or less stable circulation. (Crit Care Med 1993; 21:659–665)" @default.
- W1973171307 created "2016-06-24" @default.
- W1973171307 creator A5029378373 @default.
- W1973171307 creator A5065350811 @default.
- W1973171307 creator A5085537818 @default.
- W1973171307 creator A5061628115 @default.
- W1973171307 date "1993-05-01" @default.
- W1973171307 modified "2023-10-16" @default.
- W1973171307 title "Safety of low-dose intraoperative bicarbonate therapy" @default.
- W1973171307 doi "https://doi.org/10.1097/00003246-199305000-00007" @default.
- W1973171307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8386997" @default.
- W1973171307 hasPublicationYear "1993" @default.
- W1973171307 type Work @default.
- W1973171307 sameAs 1973171307 @default.
- W1973171307 citedByCount "26" @default.
- W1973171307 countsByYear W19731713072014 @default.
- W1973171307 countsByYear W19731713072015 @default.
- W1973171307 countsByYear W19731713072017 @default.
- W1973171307 countsByYear W19731713072019 @default.
- W1973171307 countsByYear W19731713072020 @default.
- W1973171307 countsByYear W19731713072021 @default.
- W1973171307 countsByYear W19731713072023 @default.
- W1973171307 crossrefType "journal-article" @default.
- W1973171307 hasAuthorship W1973171307A5029378373 @default.
- W1973171307 hasAuthorship W1973171307A5061628115 @default.
- W1973171307 hasAuthorship W1973171307A5065350811 @default.
- W1973171307 hasAuthorship W1973171307A5085537818 @default.
- W1973171307 hasConcept C126322002 @default.
- W1973171307 hasConcept C147789679 @default.
- W1973171307 hasConcept C185592680 @default.
- W1973171307 hasConcept C2776420369 @default.
- W1973171307 hasConcept C2776779939 @default.
- W1973171307 hasConcept C2777080012 @default.
- W1973171307 hasConcept C2778553927 @default.
- W1973171307 hasConcept C2779246250 @default.
- W1973171307 hasConcept C2780807750 @default.
- W1973171307 hasConcept C2781112554 @default.
- W1973171307 hasConcept C42219234 @default.
- W1973171307 hasConcept C71924100 @default.
- W1973171307 hasConceptScore W1973171307C126322002 @default.
- W1973171307 hasConceptScore W1973171307C147789679 @default.
- W1973171307 hasConceptScore W1973171307C185592680 @default.
- W1973171307 hasConceptScore W1973171307C2776420369 @default.
- W1973171307 hasConceptScore W1973171307C2776779939 @default.
- W1973171307 hasConceptScore W1973171307C2777080012 @default.
- W1973171307 hasConceptScore W1973171307C2778553927 @default.
- W1973171307 hasConceptScore W1973171307C2779246250 @default.
- W1973171307 hasConceptScore W1973171307C2780807750 @default.
- W1973171307 hasConceptScore W1973171307C2781112554 @default.
- W1973171307 hasConceptScore W1973171307C42219234 @default.
- W1973171307 hasConceptScore W1973171307C71924100 @default.
- W1973171307 hasIssue "5" @default.
- W1973171307 hasLocation W19731713071 @default.
- W1973171307 hasLocation W19731713072 @default.
- W1973171307 hasOpenAccess W1973171307 @default.
- W1973171307 hasPrimaryLocation W19731713071 @default.
- W1973171307 hasRelatedWork W1531824061 @default.
- W1973171307 hasRelatedWork W1969358452 @default.
- W1973171307 hasRelatedWork W1973171307 @default.
- W1973171307 hasRelatedWork W2016548969 @default.
- W1973171307 hasRelatedWork W2040330108 @default.
- W1973171307 hasRelatedWork W2044302200 @default.
- W1973171307 hasRelatedWork W2073074692 @default.
- W1973171307 hasRelatedWork W2330770260 @default.
- W1973171307 hasRelatedWork W2406939132 @default.
- W1973171307 hasRelatedWork W4382541634 @default.
- W1973171307 hasVolume "21" @default.
- W1973171307 isParatext "false" @default.
- W1973171307 isRetracted "false" @default.
- W1973171307 magId "1973171307" @default.
- W1973171307 workType "article" @default.