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- W1973171472 abstract "Abstract The glucosiduronates of some important urinary metabolites of cortisol are determined using a differential gas Chromatographic method. The steroids quantitatad are the four major 11-oxygenated-17-oxosteroids; tetrahydrocortisone (5β-pregnane-3α,17α, 21-triol-11, 20-dione), tetrahydrocortisol (5β pregnane-3 α, 11β, 17α, 21-tetrol-20-one), cortolones (5β-pregnane-3α, 17α, 20α +20β,21-tetrol-11-one) and cortols (5β-pregnane-3α, 11β, 17α, 20α + 20β,21-pentol; and the four corresponding 5α-H stereoisomers of these. Following enzyme hydrolysis of the extracted conjugates, three equivalent fractions are prepared. One is unoxidised, the second oxidised with bismuthate and the third with periodate. After formylation and chromatography of the three fractions, each is oxidised with dichromate-acetic acid specifically to convert 11β-hydroxyl to 11-oxo-groups. The new residues are dissolved and chromatographed. Adrenosterone (androst-4-ene-3, 11, 17-trione) is used as internal standards. All steroids of interest are thus finally measured differentially as the formates of either 5β-androstan-3α-ol–11,17-dione or its 5α-H, isomer. Values are given for 14 normal people. Where previous data exist, the present values agree well with them. Outputs for men and women are not significantly different when expressed relative to creatinine output. The method should be useful in studying the changes in metabolic patterns occurring in various pathological conditions." @default.
- W1973171472 created "2016-06-24" @default.
- W1973171472 creator A5079779288 @default.
- W1973171472 date "1971-11-01" @default.
- W1973171472 modified "2023-09-25" @default.
- W1973171472 title "Gas chromatographic quantitation of steroids in health ahd disease part 4. Determination of conjugated cortisol metabolites in urine" @default.
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- W1973171472 doi "https://doi.org/10.1016/0039-128x(71)90075-4" @default.
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