FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973176724> ?p ?o ?g. }

• W1973176724 endingPage "60" @default.
• W1973176724 startingPage "51" @default.
• W1973176724 abstract "The stress-related neurohormonal peptides corticotropin-releasing factor (CRF) and urotensin-I (U-I), an ortholog of mammalian urocortin 1, are widely distributed in the central nervous systems of teleost fish but little is known about their possible central neurotropic actions. In the present study, we investigated the effect of intracerebroventricular (ICV) injection of CRF and U-I (1-10pmol) on ventilatory and cardiovascular variables in our established unanaesthetized trout model. CRF and U-I produced a significant dose-dependent and long-lasting increase in the ventilatory frequency (VF) and the ventilatory amplitude (VA). Consequently the net effect of these peptides was a hyperventilatory response since the total ventilation (VTOT) was significantly elevated. However, CRF evoked a significant hyperventilatory response 5-10min sooner than that observed after ICV administration of U-I and the hyperventilatory effect of 10pmol CRF was twofold higher than that of equimolar dose of U-I. Pre-treatment of the trout with the antagonist, alpha-helical CRF(9-41), significantly reduced by about threefold the CRF-induced increase in VF, VA and VTOT. The most significant cardiovascular action of central CRF and U-I was to evoke a hypertensive response without changing the heart rate. Peripheral injection of CRF and U-I at doses of 5 and 50pmol produced no change in VF, VA or VTOT. Only a transient hypertensive response without change in heart rate was observed after the injection of the highest dose of U-I. Our results demonstrate that in a teleost fish, CRF and U-I produce a potent hyperventilatory response only when injected centrally. The two endogenous stress-related neuropeptides may play an important stimulatory role acting as neurotransmitters and/or neuromodulators in the central control of ventilatory apparatus during stress." @default.
• W1973176724 created "2016-06-24" @default.
• W1973176724 creator A5004865471 @default.
• W1973176724 creator A5010240157 @default.
• W1973176724 creator A5069671032 @default.
• W1973176724 creator A5085817026 @default.
• W1973176724 date "2009-10-01" @default.
• W1973176724 modified "2023-09-25" @default.
• W1973176724 title "Central hyperventilatory action of the stress-related neurohormonal peptides, corticotropin-releasing factor and urotensin-I in the trout Oncorhynchus mykiss" @default.
• W1973176724 cites W1971759931 @default.
• W1973176724 cites W1973452205 @default.
• W1973176724 cites W1973667643 @default.
• W1973176724 cites W1974327195 @default.
• W1973176724 cites W1989918919 @default.
• W1973176724 cites W1990862560 @default.
• W1973176724 cites W1993288925 @default.
• W1973176724 cites W2001300254 @default.
• W1973176724 cites W2001765569 @default.
• W1973176724 cites W2001787082 @default.
• W1973176724 cites W2002982644 @default.
• W1973176724 cites W2012416101 @default.
• W1973176724 cites W2014943492 @default.
• W1973176724 cites W2019150852 @default.
• W1973176724 cites W2019164797 @default.
• W1973176724 cites W2021837980 @default.
• W1973176724 cites W2021892222 @default.
• W1973176724 cites W2026453375 @default.
• W1973176724 cites W2026691067 @default.
• W1973176724 cites W2026799693 @default.
• W1973176724 cites W2034561886 @default.
• W1973176724 cites W2035229866 @default.
• W1973176724 cites W2037688283 @default.
• W1973176724 cites W2041736210 @default.
• W1973176724 cites W2049338187 @default.
• W1973176724 cites W2049436456 @default.
• W1973176724 cites W2057591467 @default.
• W1973176724 cites W2059504010 @default.
• W1973176724 cites W2061528078 @default.
• W1973176724 cites W2062294807 @default.
• W1973176724 cites W2063532284 @default.
• W1973176724 cites W2063580069 @default.
• W1973176724 cites W2070533285 @default.
• W1973176724 cites W2073385724 @default.
• W1973176724 cites W2079573879 @default.
• W1973176724 cites W2079973449 @default.
• W1973176724 cites W2080045217 @default.
• W1973176724 cites W2085764864 @default.
• W1973176724 cites W2087299407 @default.
• W1973176724 cites W2091073441 @default.
• W1973176724 cites W2094093475 @default.
• W1973176724 cites W2094640629 @default.
• W1973176724 cites W2095036452 @default.
• W1973176724 cites W2099779707 @default.
• W1973176724 cites W2106339836 @default.
• W1973176724 cites W2110955276 @default.
• W1973176724 cites W2118238128 @default.
• W1973176724 cites W2138663406 @default.
• W1973176724 cites W2146178239 @default.
• W1973176724 cites W2157398451 @default.
• W1973176724 cites W2163354348 @default.
• W1973176724 cites W2166769360 @default.
• W1973176724 cites W35259421 @default.
• W1973176724 cites W4238453913 @default.
• W1973176724 cites W4249181252 @default.
• W1973176724 cites W4376848280 @default.
• W1973176724 doi "https://doi.org/10.1016/j.ygcen.2009.03.019" @default.
• W1973176724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19341734" @default.
• W1973176724 hasPublicationYear "2009" @default.
• W1973176724 type Work @default.
• W1973176724 sameAs 1973176724 @default.
• W1973176724 citedByCount "11" @default.
• W1973176724 countsByYear W19731767242012 @default.
• W1973176724 countsByYear W19731767242013 @default.
• W1973176724 countsByYear W19731767242015 @default.
• W1973176724 countsByYear W19731767242016 @default.
• W1973176724 countsByYear W19731767242018 @default.
• W1973176724 countsByYear W19731767242021 @default.
• W1973176724 crossrefType "journal-article" @default.
• W1973176724 hasAuthorship W1973176724A5004865471 @default.
• W1973176724 hasAuthorship W1973176724A5010240157 @default.
• W1973176724 hasAuthorship W1973176724A5069671032 @default.
• W1973176724 hasAuthorship W1973176724A5085817026 @default.
• W1973176724 hasConcept C126322002 @default.
• W1973176724 hasConcept C134018914 @default.
• W1973176724 hasConcept C170493617 @default.
• W1973176724 hasConcept C2776885963 @default.
• W1973176724 hasConcept C2778458438 @default.
• W1973176724 hasConcept C2779363728 @default.
• W1973176724 hasConcept C2779935178 @default.
• W1973176724 hasConcept C2909208804 @default.
• W1973176724 hasConcept C2994167347 @default.
• W1973176724 hasConcept C505870484 @default.
• W1973176724 hasConcept C71315377 @default.
• W1973176724 hasConcept C71924100 @default.
• W1973176724 hasConcept C86803240 @default.
• W1973176724 hasConceptScore W1973176724C126322002 @default.
• W1973176724 hasConceptScore W1973176724C134018914 @default.
• W1973176724 hasConceptScore W1973176724C170493617 @default.

• next