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- W1973182019 abstract "Recent studies have shown that 1, 25-D may be involved in the regulation of differentiation and function of the immune system. The syndrome of resistance to 1, 25-D provides an opportunity for investigation of the role of 1, 25-D in the immune system of human subjects. In this study we examined some aspects of the immune system in 5 patients with resistance to 1, 25-D and alopecia who had defective receptors for 1, 25-D in skin fibroblasts. All patients had normal numbers of blood T and B lymphocytes and normal helper/inducer (OKT4) to suppressor/cytotoxic (OKT8) ratio. Proliferative responses to phytohemagglutinin and concanavalin A were comparable to those of normal controls. Serum IgG, IgM and IgA were within the normal range for all patients. Staphylcoccal killing and monocyte chemotaxis were comparable to controls in the one patient examined. Although phagocytosis of Candida albicans by neutrophils was normal, candidacidal activity was significantly lower (32±5% of injestede C. albicans in 1 hr) than that observed in the controls (83± 16% of injested C. albicans in 1 hr). The data indicate that 1, 25-D participates in activation of intrcellular killing of some microvbes by human neutrophils and support the view that 1, 25-D is involved in a wide range of cellular processes." @default.
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- W1973182019 date "1985-04-01" @default.
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- W1973182019 title "973 DEFECTIVE NEUTROPHIL CANDIDACIDAL ACTIVITY IN PATIENTS WITH RESISTANCE TO 1,25-DIHYDROXY-VITAMIN D3 (1,25-D) WITH ALOPECIA" @default.
- W1973182019 doi "https://doi.org/10.1203/00006450-198504000-01003" @default.
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