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- W1973184578 abstract "The present study is aimed to assess age-related structural changes in corpus callosum with stereology in 21 postmortem human brains without neuropathology, of age 65–75 (Group A, n = 7), 80–85 (Group B, n = 7), and 94–105 (Group C, n = 7) years. Cross-sectional area, fiber number and density decrease in Group B compared with Group A, then remain unchanged in Group C. Mean fiber diameter increases with age. Cross-sectional area shows strong positive correlation to fiber numbers and negative correlation to mean fiber thickness. With age, modest but significant change in fiber size including a decrease in the percentage of 1–2-μm fibers and an increase in 2–3-μm fibers was observed. Fiber density shows a steeper decline with age in the anterior compared with posterior segments. Neurodegeneration is an ongoing process where the anterior corpus callosum is more susceptible to age-related degeneration. Corpus callosum cross-sectional area atrophy is mostly related to decline in fiber number and density rather than demyelination, with preferential disruption of small caliber fibers." @default.
- W1973184578 created "2016-06-24" @default.
- W1973184578 creator A5005807695 @default.
- W1973184578 creator A5006295245 @default.
- W1973184578 date "2012-05-01" @default.
- W1973184578 modified "2023-09-24" @default.
- W1973184578 title "Age-related degeneration of corpus callosum in the 90+ years measured with stereology" @default.
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- W1973184578 doi "https://doi.org/10.1016/j.neurobiolaging.2011.10.017" @default.
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