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- W1973187633 abstract "Background: The relationship between Alzheimer's disease (AD) pathological burdens and cognitive dysfunction still remain unclear. This study aimed to investigate the relationships of global cognitive dysfunction with cerebral beta-amyloid beta (burden and synaptic dysfunction, measured by [11 C]-labeled Pittsburgh Compound B (PiB)-positron emission tomography (PET) and [18 F] fluorodeoxyglucose (FDG)-PET, respectively, in cognitively normal (CN), mild cognitive impairment (MCI) and AD dementia. Twenty nine cognitively normal (CN) elderly, 30 subjects with mild cognitive impairment (MCI), and 26 with AD underwent clinical evaluation, PiB-PET and FDG-PET scanning. Two total scores (TS-l and TS-ll) of the Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery (CERAD-NP) were calculated. Data were analyzed on a voxel-basis using statistical parametric mapping 2. Each TS was used as a covariate to find regions showing significant voxel-wise correlations (linear regression models adjusted for demographic influences). For whole group, both TS showed negative correlations with Aβ deposition in frontal and temporopaietal regions. Similarly, both TSs showed positive correlations with regional cerebral glucose metabolism (rCMglc) in frontal and temporopaietal regions. In CN, both TSs showed negative correlations with Aβ deposition in left fusiform, left lingual gyrus, left inferior frontal gyrus and bilateral subcortical regions. TS-l showed positive correlations with rCMglc in left precuneus and right cuneus and TS-ll showed correlations in the slightly wider areas including bilateral parietal and frontal gyri and left temporal gyus. In regard of MCI, both TSs showed positive correlations with rCMglc in the bilateral frontal gyri and bilateral thalamus, whereas no correlation between each TS and Aβ deposition was found. For AD, TS-l showed positive correlations with rCMglc in right inferior temporal gyrus and TS-ll showed correlations in bilateral inferior temporal gyri, whereas any correlation between each TS and Aβ deposition was not found. Our results suggest that although both cerebral Aβ burden and synaptic dysfunction have close relationships with general cognition, each of them probably makes differential contributions to cognitive decline according to the cognitive subgroups." @default.
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- W1973187633 date "2012-07-01" @default.
- W1973187633 modified "2023-09-27" @default.
- W1973187633 title "P3-175: Relationships between global cognitive dysfunction and PET biomarkers in normal aging, mild cognitive impairment and Alzheimer's disease" @default.
- W1973187633 doi "https://doi.org/10.1016/j.jalz.2012.05.1395" @default.
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