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- W1973189165 abstract "Tyrosine phosphorylation is one of the key covalent modifications that occur in multicellular organisms. Since its discovery more than 30 years ago, tyrosine phosphorylation has come to be understood as a fundamentally important mechanism of signal transduction and regulation in all eukaryotic cells. The tyrosine kinase Lck (lymphocyte-specific protein tyrosine kinase) plays a crucial role in the T-cell response by transducing early activation signals triggered by TCR (T-cell receptor) engagement. These signals result in the phosphorylation of immunoreceptor tyrosine-based activation motifs present within the cytosolic tails of the TCR-associated CD3 subunits that, once phosphorylated, serve as scaffolds for the assembly of a large supramolecular signalling complex responsible for T-cell activation. The existence of membrane nano- or micro-domains or rafts as specialized platforms for protein transport and cell signalling has been proposed. The present review discusses the signals that target Lck to membrane rafts and the importance of these specialized membranes in the transport of Lck to the plasma membrane, the regulation of Lck activity and the phosphorylation of the TCR." @default.
- W1973189165 created "2016-06-24" @default.
- W1973189165 creator A5016622788 @default.
- W1973189165 creator A5023973233 @default.
- W1973189165 date "2013-08-09" @default.
- W1973189165 modified "2023-10-02" @default.
- W1973189165 title "The role of membrane rafts in Lck transport, regulation and signalling in T-cells" @default.
- W1973189165 cites W1524455540 @default.
- W1973189165 cites W1529013613 @default.
- W1973189165 cites W1548747789 @default.
- W1973189165 cites W1550431800 @default.
- W1973189165 cites W1553517909 @default.
- W1973189165 cites W1562441478 @default.
- W1973189165 cites W1564861448 @default.
- W1973189165 cites W1582379379 @default.
- W1973189165 cites W1599959056 @default.
- W1973189165 cites W1601798272 @default.
- W1973189165 cites W1631158375 @default.
- W1973189165 cites W1906673334 @default.
- W1973189165 cites W1934912969 @default.
- W1973189165 cites W1955581709 @default.
- W1973189165 cites W1963569988 @default.
- W1973189165 cites W1963844499 @default.
- W1973189165 cites W1965712069 @default.
- W1973189165 cites W1969461041 @default.
- W1973189165 cites W1971692004 @default.
- W1973189165 cites W1974561108 @default.
- W1973189165 cites W1975798362 @default.
- W1973189165 cites W1980422861 @default.
- W1973189165 cites W1980843814 @default.
- W1973189165 cites W1981700749 @default.
- W1973189165 cites W1981913963 @default.
- W1973189165 cites W1982441198 @default.
- W1973189165 cites W1982486689 @default.
- W1973189165 cites W1984008114 @default.
- W1973189165 cites W1988530230 @default.
- W1973189165 cites W1989292831 @default.
- W1973189165 cites W1989488426 @default.
- W1973189165 cites W1990678679 @default.
- W1973189165 cites W1991241713 @default.
- W1973189165 cites W1991683855 @default.
- W1973189165 cites W1992504446 @default.
- W1973189165 cites W1992910677 @default.
- W1973189165 cites W1994772282 @default.
- W1973189165 cites W1996605553 @default.
- W1973189165 cites W1999236343 @default.
- W1973189165 cites W2001217082 @default.
- W1973189165 cites W2001358928 @default.
- W1973189165 cites W2002473468 @default.
- W1973189165 cites W2002943021 @default.
- W1973189165 cites W2007012258 @default.
- W1973189165 cites W2008649874 @default.
- W1973189165 cites W2013247312 @default.
- W1973189165 cites W2013455252 @default.
- W1973189165 cites W2014574326 @default.
- W1973189165 cites W2015975352 @default.
- W1973189165 cites W2019300008 @default.
- W1973189165 cites W2020279663 @default.
- W1973189165 cites W2022204362 @default.
- W1973189165 cites W2023930071 @default.
- W1973189165 cites W2024913007 @default.
- W1973189165 cites W2025748968 @default.
- W1973189165 cites W2025823475 @default.
- W1973189165 cites W2028669354 @default.
- W1973189165 cites W2032062053 @default.
- W1973189165 cites W2032747664 @default.
- W1973189165 cites W2033820909 @default.
- W1973189165 cites W2035562653 @default.
- W1973189165 cites W2039998576 @default.
- W1973189165 cites W2040611486 @default.
- W1973189165 cites W2047721855 @default.
- W1973189165 cites W2048000803 @default.
- W1973189165 cites W2050788151 @default.
- W1973189165 cites W2052935616 @default.
- W1973189165 cites W2055600777 @default.
- W1973189165 cites W2055981013 @default.
- W1973189165 cites W2058728729 @default.
- W1973189165 cites W2061604045 @default.
- W1973189165 cites W2065289702 @default.
- W1973189165 cites W2065535173 @default.
- W1973189165 cites W2068503298 @default.
- W1973189165 cites W2068504553 @default.
- W1973189165 cites W2072659663 @default.
- W1973189165 cites W2072877277 @default.
- W1973189165 cites W2074416628 @default.
- W1973189165 cites W2075121503 @default.
- W1973189165 cites W2075451080 @default.
- W1973189165 cites W2076601151 @default.
- W1973189165 cites W2076894371 @default.
- W1973189165 cites W2080136687 @default.
- W1973189165 cites W2080367647 @default.
- W1973189165 cites W2085625466 @default.
- W1973189165 cites W2086235697 @default.
- W1973189165 cites W2093365663 @default.
- W1973189165 cites W2093909262 @default.
- W1973189165 cites W2099204510 @default.
- W1973189165 cites W2099593237 @default.
- W1973189165 cites W2099887519 @default.