FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973190757> ?p ?o ?g. }

• W1973190757 endingPage "839" @default.
• W1973190757 startingPage "831" @default.
• W1973190757 abstract "Aromatase is a cytochrome P-450 enzyme complex that catalyzes the conversion of androst-4-ene-3,17-dione (AD) to estrone through three sequential oxidations of the 19-methyl group. 3-DeoxyAD (1) and its 5-ene isomer 4 are potent and good competitive aromatase inhibitors, which are converted by aromatase to the aldehyde derivatives 3 and 6, respectively, through 19-hydroxy intermediates 2 and 5, respectively. To study the deuterium isotope effect on the conversions of 19-ols 2 and 5 into the corresponding 19-als 3 and 6, we initially synthesized [19,19-(2)H(2)]19-ols 2 and 5 starting from the corresponding non-labeled 19-als 3 and 6 through NaB(2)H(4) reduction of the 19-aldehyde group, followed by oxidation with pyridinium dichromate, and a subsequent NaB(2)H(4) reduction. Approximately 1:1 mixtures of non-labeled (d(0)) and deuterated (d(2)) 19-ols 2 and 5 were separately incubated with human placental microsomes in the presence of NADPH under an air atmosphere, and deuterium contents of the recovered substrates and the 19-aldehyde products were determined by gas chromatography-mass spectrometry. In each experiment, the ratio of d(0) to d(2) of the recovered substrate along with that of d(0) to d(1) of the product were identical to the d(0) to d(2) ratio of the employed substrate irrespective of the incubation time, indicating that the 19-oxygenations of the 3-deoxy steroids 2 and 5 proceeded without a detectable isotope effect, as seen in the aromatization sequence of the natural substrate AD." @default.
• W1973190757 created "2016-06-24" @default.
• W1973190757 creator A5018880789 @default.
• W1973190757 creator A5076077307 @default.
• W1973190757 date "2005-11-01" @default.
• W1973190757 modified "2023-09-27" @default.
• W1973190757 title "Gas chromatography–mass spectrometric analysis of oxidative reactions of [19,19-2H2]19-hydroxy-3-deoxy androgens by placental aromataseAbsence of a deuterium-isotope effect" @default.
• W1973190757 cites W1537291268 @default.
• W1973190757 cites W1547953895 @default.
• W1973190757 cites W1601438131 @default.
• W1973190757 cites W1974553522 @default.
• W1973190757 cites W1975206720 @default.
• W1973190757 cites W1978043916 @default.
• W1973190757 cites W1978651949 @default.
• W1973190757 cites W1987198530 @default.
• W1973190757 cites W2010650740 @default.
• W1973190757 cites W2015325021 @default.
• W1973190757 cites W2016456093 @default.
• W1973190757 cites W2016708089 @default.
• W1973190757 cites W2017938732 @default.
• W1973190757 cites W2038245463 @default.
• W1973190757 cites W2040500942 @default.
• W1973190757 cites W2046020527 @default.
• W1973190757 cites W2047537806 @default.
• W1973190757 cites W2056326238 @default.
• W1973190757 cites W2057727568 @default.
• W1973190757 cites W2058024995 @default.
• W1973190757 cites W2073601662 @default.
• W1973190757 cites W2074958902 @default.
• W1973190757 cites W2076975461 @default.
• W1973190757 cites W2151224813 @default.
• W1973190757 cites W2343311792 @default.
• W1973190757 cites W2460927423 @default.
• W1973190757 cites W2949205585 @default.
• W1973190757 cites W3004933788 @default.
• W1973190757 doi "https://doi.org/10.1016/j.steroids.2005.04.009" @default.
• W1973190757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16002112" @default.
• W1973190757 hasPublicationYear "2005" @default.
• W1973190757 type Work @default.
• W1973190757 sameAs 1973190757 @default.
• W1973190757 citedByCount "3" @default.
• W1973190757 crossrefType "journal-article" @default.
• W1973190757 hasAuthorship W1973190757A5018880789 @default.
• W1973190757 hasAuthorship W1973190757A5076077307 @default.
• W1973190757 hasConcept C111368507 @default.
• W1973190757 hasConcept C121332964 @default.
• W1973190757 hasConcept C121608353 @default.
• W1973190757 hasConcept C126322002 @default.
• W1973190757 hasConcept C127313418 @default.
• W1973190757 hasConcept C155647269 @default.
• W1973190757 hasConcept C161790260 @default.
• W1973190757 hasConcept C162356407 @default.
• W1973190757 hasConcept C178790620 @default.
• W1973190757 hasConcept C181199279 @default.
• W1973190757 hasConcept C185592680 @default.
• W1973190757 hasConcept C2776166826 @default.
• W1973190757 hasConcept C2776317432 @default.
• W1973190757 hasConcept C2777289219 @default.
• W1973190757 hasConcept C2778656385 @default.
• W1973190757 hasConcept C2779825165 @default.
• W1973190757 hasConcept C40875361 @default.
• W1973190757 hasConcept C43617362 @default.
• W1973190757 hasConcept C530470458 @default.
• W1973190757 hasConcept C55493867 @default.
• W1973190757 hasConcept C58364064 @default.
• W1973190757 hasConcept C62520636 @default.
• W1973190757 hasConcept C69928629 @default.
• W1973190757 hasConcept C71240020 @default.
• W1973190757 hasConcept C71315377 @default.
• W1973190757 hasConcept C71924100 @default.
• W1973190757 hasConcept C87644729 @default.
• W1973190757 hasConceptScore W1973190757C111368507 @default.
• W1973190757 hasConceptScore W1973190757C121332964 @default.
• W1973190757 hasConceptScore W1973190757C121608353 @default.
• W1973190757 hasConceptScore W1973190757C126322002 @default.
• W1973190757 hasConceptScore W1973190757C127313418 @default.
• W1973190757 hasConceptScore W1973190757C155647269 @default.
• W1973190757 hasConceptScore W1973190757C161790260 @default.
• W1973190757 hasConceptScore W1973190757C162356407 @default.
• W1973190757 hasConceptScore W1973190757C178790620 @default.
• W1973190757 hasConceptScore W1973190757C181199279 @default.
• W1973190757 hasConceptScore W1973190757C185592680 @default.
• W1973190757 hasConceptScore W1973190757C2776166826 @default.
• W1973190757 hasConceptScore W1973190757C2776317432 @default.
• W1973190757 hasConceptScore W1973190757C2777289219 @default.
• W1973190757 hasConceptScore W1973190757C2778656385 @default.
• W1973190757 hasConceptScore W1973190757C2779825165 @default.
• W1973190757 hasConceptScore W1973190757C40875361 @default.
• W1973190757 hasConceptScore W1973190757C43617362 @default.
• W1973190757 hasConceptScore W1973190757C530470458 @default.
• W1973190757 hasConceptScore W1973190757C55493867 @default.
• W1973190757 hasConceptScore W1973190757C58364064 @default.
• W1973190757 hasConceptScore W1973190757C62520636 @default.
• W1973190757 hasConceptScore W1973190757C69928629 @default.
• W1973190757 hasConceptScore W1973190757C71240020 @default.
• W1973190757 hasConceptScore W1973190757C71315377 @default.
• W1973190757 hasConceptScore W1973190757C71924100 @default.
• W1973190757 hasConceptScore W1973190757C87644729 @default.

• next