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• W1973202110 endingPage "461" @default.
• W1973202110 startingPage "447" @default.
• W1973202110 abstract "Members of the Frizzled family of integral membrane proteins are implicated in many developmental events, including specifying cell fate, orienting cell and planar polarity, and directing cell migration. Frizzleds function as cell surface receptors for secreted Wnt proteins. We report here the isolation of a mutation in cfz-2, a Caenorhabditis elegans Frizzled gene. Mutation of cfz-2 causes defective cell migration, disorganization of head neurons, and can cause ectopic axon outgrowth. Analysis of mosaic animals shows that CFZ-2 functions cell nonautonomously, but does not rule out an autonomous role. CFZ-2 is expressed primarily in the anterior of embryos and in several cells in the head of adults. Our analysis of interactions between CFZ-2 and other Wnt pathways reveals that three Wnts, CWN-1, CWN-2 and EGL-20, and a Frizzled, MOM-5, function redundantly with one another and with CFZ-2 for specific cell migrations. In contrast, CWN-1, CWN-2, EGL-20, CFZ-2, and MOM-5 antagonize one another for other migrations. Therefore, CFZ-2 functions by collaborating with and/or antagonizing other Wnt signaling pathways to regulate specific cell migrations." @default.
• W1973202110 created "2016-06-24" @default.
• W1973202110 creator A5051982131 @default.
• W1973202110 creator A5076528377 @default.
• W1973202110 date "2005-09-01" @default.
• W1973202110 modified "2023-10-14" @default.
• W1973202110 title "The C. elegans Frizzled CFZ-2 is required for cell migration and interacts with multiple Wnt signaling pathways" @default.
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• W1973202110 doi "https://doi.org/10.1016/j.ydbio.2005.07.014" @default.
• W1973202110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16109397" @default.
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