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• W1973206977 abstract "—(1) Fluxes of sodium, potassium, chloride and glutamate ions were studied in brain slices by aid of radio-isotopes. Desaturation curves showed the efflux to occur from at least two compartments with widely different kinetics. (2) The slowly exchanging component comprises from about 10 (sodium, potassium, chloride) to about 30 (glutamate) per cent of the radioactivity in the tissue. An energy-requiring uptake of potassium and extrusion of sodium seems to occur in this compartment, which probably includes the nerve cells. (3) A rather slow efflux of especially potassium ions from the rapidly exchanging fraction indicates that this component may not be purely extracellular, but also seems to include cells, which possibly are neuroglial. The hypothesis of a cellular origin is supported by the demonstration of an increase in the rate constant of the potassium efflux evoked in the presence of oxygen by high concentrations of potassium. (4) Evidence is presented that the increase in the rate constant of the potassium efflux is due to a potassium-induced stimulation of active transport. No coupling seems to occur between the stimulated potassium transport and movements of sodium, but potassium ions may be accompanied by glutamate ions." @default.
• W1973206977 created "2016-06-24" @default.
• W1973206977 creator A5061796601 @default.
• W1973206977 date "1968-01-01" @default.
• W1973206977 modified "2023-09-26" @default.
• W1973206977 title "POTASSIUM EFFECTS ON ION TRANSPORT IN BRAIN SLICES" @default.
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• W1973206977 doi "https://doi.org/10.1111/j.1471-4159.1968.tb06167.x" @default.
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