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• W1973210171 abstract "Herein we report that the lipid kinase sphingosine kinase-1 (SphK1) is instrumental in mediating androgen-induced cell proliferation in osteoblasts. Dihydrotestosterone (DHT) triggered cell growth in steroid-deprived MC3T3 cells, which was associated with a rapid stimulation of SphK1 and activation of both Akt and ERK signaling pathways. This mechanism relied on functional androgen receptor/PI3K/Akt nongenotropic signaling as pharmacological antagonists could block SphK1 stimulation by DHT and its consequences. Finally, SphK1 inhibition not only abrogated DHT-induced ERK activation but also blocked cell proliferation, while ERK inhibition had no impact, suggesting that SphK1 was critical for DHT signaling yet independently of the ERK." @default.
• W1973210171 created "2016-06-24" @default.
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• W1973210171 date "2010-01-01" @default.
• W1973210171 modified "2023-10-18" @default.
• W1973210171 title "Sphingosine kinase-1 mediates androgen-induced osteoblast cell growth" @default.
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• W1973210171 doi "https://doi.org/10.1016/j.bbrc.2009.11.118" @default.
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