FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973217811> ?p ?o ?g. }

• W1973217811 endingPage "918" @default.
• W1973217811 startingPage "912" @default.
• W1973217811 abstract "Multiple E2F1 phosphorylation sites have been described as targets of different kinases, yet their in vivo implication is uncertain. We previously reported that GSK3beta is able to phosphorylate E2F1 in vitro at Ser403 and Ser433. Recently, it has been shown that both residues are also direct targets of p38 MAP kinase. In order to determine whether Ser403 phosphorylation occurs in vivo and to elucidate its role in E2F1 transcription activity, we developed a phospho-E2F1(Ser403) antibody for use in in vivo detection studies. Our results demonstrate that endogenous E2F1 is phosphorylated in vivo on Ser403, however neither GSK3beta nor p38 MAP kinase are responsible for this event. E2F1 phosphorylation on Ser403 is induced after treatment with doxorubicin in a dose response manner. The transcriptional response of E2F1 to doxorubicin is lower in an E2F1 Ser/Ala403 mutated construct relative to the wild type, suggesting a role for Ser403 phosphorylation in DNA damage conditions. Comparative study between the expression of the bcl2 gene family induced by the wild type and E2F1 Ser/Ala403 mutant revealed a statistically different pattern between both conditions. These results suggest that phosphorylation of Ser403 could influence the selection and regulation of E2F1 target genes." @default.
• W1973217811 created "2016-06-24" @default.
• W1973217811 creator A5004382869 @default.
• W1973217811 creator A5006363616 @default.
• W1973217811 creator A5058865732 @default.
• W1973217811 creator A5065080458 @default.
• W1973217811 creator A5090296941 @default.
• W1973217811 date "2010-08-01" @default.
• W1973217811 modified "2023-10-01" @default.
• W1973217811 title "Study of the in vivo phosphorylation of E2F1 on Ser403" @default.
• W1973217811 cites W1520563041 @default.
• W1973217811 cites W1762601366 @default.
• W1973217811 cites W1972343960 @default.
• W1973217811 cites W1982958012 @default.
• W1973217811 cites W1982989725 @default.
• W1973217811 cites W1987325811 @default.
• W1973217811 cites W1995767597 @default.
• W1973217811 cites W2011968815 @default.
• W1973217811 cites W2015680924 @default.
• W1973217811 cites W2019897778 @default.
• W1973217811 cites W2021390529 @default.
• W1973217811 cites W2021568883 @default.
• W1973217811 cites W2022914311 @default.
• W1973217811 cites W2023283617 @default.
• W1973217811 cites W2029327556 @default.
• W1973217811 cites W2032729242 @default.
• W1973217811 cites W2036575025 @default.
• W1973217811 cites W2041503766 @default.
• W1973217811 cites W2047660841 @default.
• W1973217811 cites W2052547687 @default.
• W1973217811 cites W2054015257 @default.
• W1973217811 cites W2071722374 @default.
• W1973217811 cites W2088485595 @default.
• W1973217811 cites W2100948548 @default.
• W1973217811 cites W2132475598 @default.
• W1973217811 cites W2162874742 @default.
• W1973217811 cites W2166393142 @default.
• W1973217811 doi "https://doi.org/10.1016/j.bbamcr.2010.04.003" @default.
• W1973217811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20447425" @default.
• W1973217811 hasPublicationYear "2010" @default.
• W1973217811 type Work @default.
• W1973217811 sameAs 1973217811 @default.
• W1973217811 citedByCount "18" @default.
• W1973217811 countsByYear W19732178112012 @default.
• W1973217811 countsByYear W19732178112013 @default.
• W1973217811 countsByYear W19732178112014 @default.
• W1973217811 countsByYear W19732178112015 @default.
• W1973217811 countsByYear W19732178112016 @default.
• W1973217811 countsByYear W19732178112021 @default.
• W1973217811 countsByYear W19732178112023 @default.
• W1973217811 crossrefType "journal-article" @default.
• W1973217811 hasAuthorship W1973217811A5004382869 @default.
• W1973217811 hasAuthorship W1973217811A5006363616 @default.
• W1973217811 hasAuthorship W1973217811A5058865732 @default.
• W1973217811 hasAuthorship W1973217811A5065080458 @default.
• W1973217811 hasAuthorship W1973217811A5090296941 @default.
• W1973217811 hasBestOaLocation W19732178111 @default.
• W1973217811 hasConcept C104317684 @default.
• W1973217811 hasConcept C11960822 @default.
• W1973217811 hasConcept C153911025 @default.
• W1973217811 hasConcept C183022183 @default.
• W1973217811 hasConcept C184235292 @default.
• W1973217811 hasConcept C207001950 @default.
• W1973217811 hasConcept C54355233 @default.
• W1973217811 hasConcept C55493867 @default.
• W1973217811 hasConcept C86339819 @default.
• W1973217811 hasConcept C86803240 @default.
• W1973217811 hasConcept C95444343 @default.
• W1973217811 hasConceptScore W1973217811C104317684 @default.
• W1973217811 hasConceptScore W1973217811C11960822 @default.
• W1973217811 hasConceptScore W1973217811C153911025 @default.
• W1973217811 hasConceptScore W1973217811C183022183 @default.
• W1973217811 hasConceptScore W1973217811C184235292 @default.
• W1973217811 hasConceptScore W1973217811C207001950 @default.
• W1973217811 hasConceptScore W1973217811C54355233 @default.
• W1973217811 hasConceptScore W1973217811C55493867 @default.
• W1973217811 hasConceptScore W1973217811C86339819 @default.
• W1973217811 hasConceptScore W1973217811C86803240 @default.
• W1973217811 hasConceptScore W1973217811C95444343 @default.
• W1973217811 hasIssue "8" @default.
• W1973217811 hasLocation W19732178111 @default.
• W1973217811 hasLocation W19732178112 @default.
• W1973217811 hasOpenAccess W1973217811 @default.
• W1973217811 hasPrimaryLocation W19732178111 @default.
• W1973217811 hasRelatedWork W1964515703 @default.
• W1973217811 hasRelatedWork W1968220508 @default.
• W1973217811 hasRelatedWork W1973807900 @default.
• W1973217811 hasRelatedWork W2051108283 @default.
• W1973217811 hasRelatedWork W2057841153 @default.
• W1973217811 hasRelatedWork W2065575443 @default.
• W1973217811 hasRelatedWork W2091597364 @default.
• W1973217811 hasRelatedWork W4206118349 @default.
• W1973217811 hasRelatedWork W4362610326 @default.
• W1973217811 hasRelatedWork W4362623556 @default.
• W1973217811 hasVolume "1803" @default.
• W1973217811 isParatext "false" @default.
• W1973217811 isRetracted "false" @default.
• W1973217811 magId "1973217811" @default.

• next