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- W1973227613 abstract "In the present study, we investigated the anti-inflammatory activity of water-soluble polysaccharide of Agaricus blazei Murill (WSP-AbM) on ovariectomized osteopenic rats. The rats were administered orally WSP-AbM (200 mg/kg BW) for 8 weeks. Subsequent serum maleic dialdehyde (MDA) level, total antioxidant status (TAOS), nuclear factor kappa B (NF- κ B) level, polymorphonuclear (PMN) cells level, interleukin-1 β (IL-1 β ) level, inducible nitric oxide synthase (iNOS) level, tumor necrosis factor- α (TNF- α ) level, adhesion molecule (ICAM-1), and cyclooxygenase-2 (COX-2) were determined by enzyme linked immunosorbent assay (ELISA) and immunohistochemistry, respectively. WSP-AbM administration markedly (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0</mml:mn><mml:mo>.</mml:mo><mml:mn>05</mml:mn></mml:math>) decreased serum IL-1 β and TNF- α levels and the expressions of ICAM-1, COX-2, and iNOS NF- κ B compared with OVX rats. WSP-AbM administration alsomarkedly (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0</mml:mn><mml:mo>.</mml:mo><mml:mn>05</mml:mn></mml:math>) decreased PMN infiltration. In conclusion, we observed that WSP-AbM supplementation had anti-inflammatory effects in a model of osteoporosis disease." @default.
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- W1973227613 date "2013-01-01" @default.
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- W1973227613 title "Anti-Inflammatory Activity of Water-Soluble Polysaccharide of<i>Agaricus blazei</i>Murill on Ovariectomized Osteopenic Rats" @default.
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- W1973227613 doi "https://doi.org/10.1155/2013/164817" @default.
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