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- W1973237254 abstract "Neuroglobin, a new member of hemoprotein family, can reversibly bind oxygen and take part in many biological processes such as enzymatic reaction, signal transduction and the mitochondria function. Different from myoglobin and hemoglobin, it has a hexacoordinated heme environment, with histidyl imidazole of proximal His(96)(F8) and distal His(64)(E7) directly bound to the metal ion. In the present work, solution (1)H NMR spectroscopy was employed to investigate the electronic structure of heme center of wild-type met-human neuroglobin. The resonances of heme protons and key residues in the heme pocket were assigned. Two heme orientations resulting from a 180 degrees rotation about the alpha-gamma-meso axis with a population ratio about 2:1 were observed. Then the (1)H NMR chemical shifts of the ferriheme methyl groups were used to predict orientations of the axial ligand. The obtained axial ligand plane angle phi is consistent with that from the molecular dynamics simulation but not with those from the crystal data. Compared with mouse neuroglobin, the obtained average ligand orientation of human neuroglobin reflects the changeability of heme environment for the Ngb family." @default.
- W1973237254 created "2016-06-24" @default.
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- W1973237254 date "2009-12-01" @default.
- W1973237254 modified "2023-09-25" @default.
- W1973237254 title "Ligand orientation of human neuroglobin obtained from solution NMR and molecular dynamics simulation as compared with X-ray crystallography" @default.
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- W1973237254 doi "https://doi.org/10.1016/j.jinorgbio.2009.09.016" @default.
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