FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973240167> ?p ?o ?g. }

• W1973240167 endingPage "3584" @default.
• W1973240167 startingPage "3578" @default.
• W1973240167 abstract "In the present work a chimeric receptor containing the intracellular domain of the insulin receptor-related receptor (IRR) and the extracellular domain of the colony stimulating factor-1 (CSF-1) receptor was expressed in 3T3-L1 adipocytes and compared with the parallel chimeric receptor containing the cytoplasmic domain of the insulin receptor (IR). Both chimeric receptors exhibited CSF-stimulated tyrosine kinase activity when assayed in vitro after in vivo activation comparable to that of the endogenous IR present in these cells. No cross-activation of the expressed chimeric and endogenous receptors was observed. The cytoplasmic domain of the IRR was found to 1) mediate activation of the Ser/Thr kinase Akt/PKB, 2) stimulate glucose uptake, 3) inhibit lipolysis, and 4) stimulate glycogen synthase, all with a potency comparable to those of the expressed CSF-1R/IR chimera and the endogenous insulin receptors. These results indicate that despite the extensive differences in sequence between the cytoplasmic domains of the IRR and IR, the elements required for insulin-specific responses have been conserved in this distinct member of the insulin receptor family." @default.
• W1973240167 created "2016-06-24" @default.
• W1973240167 creator A5033862891 @default.
• W1973240167 creator A5035975207 @default.
• W1973240167 creator A5038282250 @default.
• W1973240167 creator A5088254132 @default.
• W1973240167 date "1998-08-01" @default.
• W1973240167 modified "2023-10-16" @default.
• W1973240167 title "Comparison of the Signaling Abilities of the Cytoplasmic Domains of the Insulin Receptor and the Insulin Receptor-Related Receptor in 3T3-L1 Adipocytes1" @default.
• W1973240167 cites W1541642856 @default.
• W1973240167 cites W1611264534 @default.
• W1973240167 cites W1645045349 @default.
• W1973240167 cites W1654852813 @default.
• W1973240167 cites W1931843124 @default.
• W1973240167 cites W1970529208 @default.
• W1973240167 cites W1976910992 @default.
• W1973240167 cites W1986420181 @default.
• W1973240167 cites W1989294105 @default.
• W1973240167 cites W1990634454 @default.
• W1973240167 cites W1995100735 @default.
• W1973240167 cites W2001322388 @default.
• W1973240167 cites W2012523703 @default.
• W1973240167 cites W2016891712 @default.
• W1973240167 cites W2017663156 @default.
• W1973240167 cites W2019802189 @default.
• W1973240167 cites W2022183896 @default.
• W1973240167 cites W2023192022 @default.
• W1973240167 cites W2057763334 @default.
• W1973240167 cites W2058017945 @default.
• W1973240167 cites W2058390591 @default.
• W1973240167 cites W2059692699 @default.
• W1973240167 cites W2084677159 @default.
• W1973240167 cites W2088021829 @default.
• W1973240167 cites W2112009693 @default.
• W1973240167 cites W2127078056 @default.
• W1973240167 cites W2140884727 @default.
• W1973240167 cites W2152127342 @default.
• W1973240167 cites W2165863663 @default.
• W1973240167 cites W2178492210 @default.
• W1973240167 cites W650008823 @default.
• W1973240167 cites W6823376 @default.
• W1973240167 cites W89084389 @default.
• W1973240167 doi "https://doi.org/10.1210/endo.139.8.6165" @default.
• W1973240167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9681510" @default.
• W1973240167 hasPublicationYear "1998" @default.
• W1973240167 type Work @default.
• W1973240167 sameAs 1973240167 @default.
• W1973240167 citedByCount "14" @default.
• W1973240167 countsByYear W19732401672013 @default.
• W1973240167 countsByYear W19732401672017 @default.
• W1973240167 crossrefType "journal-article" @default.
• W1973240167 hasAuthorship W1973240167A5033862891 @default.
• W1973240167 hasAuthorship W1973240167A5035975207 @default.
• W1973240167 hasAuthorship W1973240167A5038282250 @default.
• W1973240167 hasAuthorship W1973240167A5088254132 @default.
• W1973240167 hasBestOaLocation W19732401671 @default.
• W1973240167 hasConcept C101544691 @default.
• W1973240167 hasConcept C112446052 @default.
• W1973240167 hasConcept C126322002 @default.
• W1973240167 hasConcept C134018914 @default.
• W1973240167 hasConcept C144174609 @default.
• W1973240167 hasConcept C170493617 @default.
• W1973240167 hasConcept C185967709 @default.
• W1973240167 hasConcept C2775960820 @default.
• W1973240167 hasConcept C2777391703 @default.
• W1973240167 hasConcept C2779306644 @default.
• W1973240167 hasConcept C42362537 @default.
• W1973240167 hasConcept C55493867 @default.
• W1973240167 hasConcept C71924100 @default.
• W1973240167 hasConcept C86803240 @default.
• W1973240167 hasConcept C95444343 @default.
• W1973240167 hasConceptScore W1973240167C101544691 @default.
• W1973240167 hasConceptScore W1973240167C112446052 @default.
• W1973240167 hasConceptScore W1973240167C126322002 @default.
• W1973240167 hasConceptScore W1973240167C134018914 @default.
• W1973240167 hasConceptScore W1973240167C144174609 @default.
• W1973240167 hasConceptScore W1973240167C170493617 @default.
• W1973240167 hasConceptScore W1973240167C185967709 @default.
• W1973240167 hasConceptScore W1973240167C2775960820 @default.
• W1973240167 hasConceptScore W1973240167C2777391703 @default.
• W1973240167 hasConceptScore W1973240167C2779306644 @default.
• W1973240167 hasConceptScore W1973240167C42362537 @default.
• W1973240167 hasConceptScore W1973240167C55493867 @default.
• W1973240167 hasConceptScore W1973240167C71924100 @default.
• W1973240167 hasConceptScore W1973240167C86803240 @default.
• W1973240167 hasConceptScore W1973240167C95444343 @default.
• W1973240167 hasIssue "8" @default.
• W1973240167 hasLocation W19732401671 @default.
• W1973240167 hasLocation W19732401672 @default.
• W1973240167 hasOpenAccess W1973240167 @default.
• W1973240167 hasPrimaryLocation W19732401671 @default.
• W1973240167 hasRelatedWork W1491267816 @default.
• W1973240167 hasRelatedWork W1988699731 @default.
• W1973240167 hasRelatedWork W1989162708 @default.
• W1973240167 hasRelatedWork W2062216595 @default.
• W1973240167 hasRelatedWork W2098842401 @default.
• W1973240167 hasRelatedWork W2109607186 @default.
• W1973240167 hasRelatedWork W2111753761 @default.

• next