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- W1973242135 abstract "SUMMARY Antisera to HL-A antigens on normal or phytohaemagglutinin (PHA) -transformed lymphocytes are shown to be able to induce the killing of these target cells by normal nonimmune lymphoid cells. This activity can be shown at high dilutions of most antisera and appears to operate against all of the common HL-A antigens. The antigenic specificity of the HL-A antisera has been determined by lymphocyte-dependent antibody (LDA) activity and compared with the specificity shown by a complement-mediated cytotoxicity test in routine use for tissue typing. General agreement between the two assays is shown—the main differences being an additional number of antigens revealed by assays of LDA. Explanations for these additional specificities are offered. Negative correlations between LDA and complement lytic assays in most cases can be shown to result from inhibition of the effector cells by the HL-A antisera. Further analysis of this inhibition by alloantisera is described. It is suggested that these studies provide substantial support for the possible importance of this cytotoxic mechanism in allograft rejection in man and form a basis for further study in this field." @default.
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- W1973242135 date "1973-07-01" @default.
- W1973242135 modified "2023-10-16" @default.
- W1973242135 title "LYMPHOCYTE-DEPENDENT CYTOTOXIC ANTIBODY ACTIVITY AGAINST HUMAN TRANSPLANTATION ANTIGENS" @default.
- W1973242135 doi "https://doi.org/10.1097/00007890-197307000-00003" @default.
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