Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973242203> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W1973242203 endingPage "S165" @default.
- W1973242203 startingPage "S165" @default.
- W1973242203 abstract "RATIONALE: To demonstrate the long-term safety and efficacy of olopatadine hydrochloride (OLO) nasal spray 665 mcg (Patanase® Nasal Spray) in patients with perennial allergic rhinitis (PAR). METHODS: This was a randomized, placebo-controlled, double-masked, parallel group study in patients > 12 years of age with a history of PAR verified by skin prick or intradermal testing. Patients received OLO or placebo (vehicle spray), 2 sprays in each nostril twice daily, for up to 1 year. An efficacy questionnaire was completed by the patient at monthly visits and adverse events, nasal, cardiovascular, and physical examination parameters were monitored throughout the study. RESULTS: Nine hundred twenty-four patients were evaluable for intent to treat analysis, including 648 patients treated for 1 year. OLO was superior to placebo in mean response to patient rated relief across all visits (2.4 versus 2.6, respectively, p<0.0001). OLO provided more than a 50% increase in symptoms-free days compared to placebo (14.9% versus 9.5%, p<0.0001). Epistaxis and bad/bitter taste were more common in patients receiving OLO. These events were mild and transient in nature. A similar incidence of nasal ulceration, infection and anatomic abnormalities compared to placebo and no adverse cardiovascular effects (including QT interval) were observed with OLO. CONCLUSIONS: Patanase® Nasal Spray administered twice daily for up to 1 year is effective in treating PAR and is associated with greater patient rated relief of symptoms and more symptom-free days than placebo. Side effects were mild and similar to those observed with other intranasal allergy products. No adverse cardiovascular effects were observed with treatment." @default.
- W1973242203 created "2016-06-24" @default.
- W1973242203 creator A5013167015 @default.
- W1973242203 date "2006-02-01" @default.
- W1973242203 modified "2023-09-26" @default.
- W1973242203 title "Safety and Efficacy of Olopatadine Hydrochloride Nasal Spray 665 mcg (Patanase® Nasal Spray) in Patients with Perennial Allergic Rhinitis" @default.
- W1973242203 doi "https://doi.org/10.1016/j.jaci.2005.12.660" @default.
- W1973242203 hasPublicationYear "2006" @default.
- W1973242203 type Work @default.
- W1973242203 sameAs 1973242203 @default.
- W1973242203 citedByCount "0" @default.
- W1973242203 crossrefType "journal-article" @default.
- W1973242203 hasAuthorship W1973242203A5013167015 @default.
- W1973242203 hasBestOaLocation W19732422031 @default.
- W1973242203 hasConcept C120665830 @default.
- W1973242203 hasConcept C121332964 @default.
- W1973242203 hasConcept C126322002 @default.
- W1973242203 hasConcept C141071460 @default.
- W1973242203 hasConcept C142724271 @default.
- W1973242203 hasConcept C197934379 @default.
- W1973242203 hasConcept C203014093 @default.
- W1973242203 hasConcept C204787440 @default.
- W1973242203 hasConcept C27081682 @default.
- W1973242203 hasConcept C2778311950 @default.
- W1973242203 hasConcept C2779789940 @default.
- W1973242203 hasConcept C2780973058 @default.
- W1973242203 hasConcept C42219234 @default.
- W1973242203 hasConcept C61511704 @default.
- W1973242203 hasConcept C71924100 @default.
- W1973242203 hasConcept C85663871 @default.
- W1973242203 hasConceptScore W1973242203C120665830 @default.
- W1973242203 hasConceptScore W1973242203C121332964 @default.
- W1973242203 hasConceptScore W1973242203C126322002 @default.
- W1973242203 hasConceptScore W1973242203C141071460 @default.
- W1973242203 hasConceptScore W1973242203C142724271 @default.
- W1973242203 hasConceptScore W1973242203C197934379 @default.
- W1973242203 hasConceptScore W1973242203C203014093 @default.
- W1973242203 hasConceptScore W1973242203C204787440 @default.
- W1973242203 hasConceptScore W1973242203C27081682 @default.
- W1973242203 hasConceptScore W1973242203C2778311950 @default.
- W1973242203 hasConceptScore W1973242203C2779789940 @default.
- W1973242203 hasConceptScore W1973242203C2780973058 @default.
- W1973242203 hasConceptScore W1973242203C42219234 @default.
- W1973242203 hasConceptScore W1973242203C61511704 @default.
- W1973242203 hasConceptScore W1973242203C71924100 @default.
- W1973242203 hasConceptScore W1973242203C85663871 @default.
- W1973242203 hasIssue "2" @default.
- W1973242203 hasLocation W19732422031 @default.
- W1973242203 hasOpenAccess W1973242203 @default.
- W1973242203 hasPrimaryLocation W19732422031 @default.
- W1973242203 hasRelatedWork W1968210320 @default.
- W1973242203 hasRelatedWork W1996598168 @default.
- W1973242203 hasRelatedWork W2013290561 @default.
- W1973242203 hasRelatedWork W2025422535 @default.
- W1973242203 hasRelatedWork W2054279456 @default.
- W1973242203 hasRelatedWork W2073444018 @default.
- W1973242203 hasRelatedWork W2095982748 @default.
- W1973242203 hasRelatedWork W2171886536 @default.
- W1973242203 hasRelatedWork W2770624586 @default.
- W1973242203 hasRelatedWork W4243470352 @default.
- W1973242203 hasVolume "117" @default.
- W1973242203 isParatext "false" @default.
- W1973242203 isRetracted "false" @default.
- W1973242203 magId "1973242203" @default.
- W1973242203 workType "article" @default.