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• W1973243344 abstract "Purpose USP-11, a member of the ubiquitin-specific protease family, has emerged as an essential regulator of double-strand break repair. Few studies have shown that silencing USP-11 led to hypersensitivity to poly(ADP-ribose) polymerase inhibition, ionizing radiation, and DNA-damaging agents. We sought to examine the predictive and prognostic relevance of USP-11 in patients treated with neoadjuvant systemic therapy (NST) for breast cancer. Methods Fifty-six women who were treated with NST for breast cancer between 1999 and 2004 were included in the study. The Kaplan-Meier product-limit method was used to estimate disease-free survival and overall survival rates. Logistic regression models were fit to determine the associations between USP-11 status, pathological complete response (pCR), and survival. Results Sixteen patients (29%) had high-USP-11–expressing tumors, and 40 (71%) patients had low-USP-11–expressing tumors. No significant differences were observed in pCR rates with respect to USP-11 status. At a median follow-up of 7.4 years, 33 patients (59%) experienced a disease recurrence or death. Patients with high-USP-11–expressing tumors had a higher risk of recurrence (odds ratio [OR], 3.87; 95% confidence interval [CI], 1.51–9.93; P = 0.005) and death (OR, 6.03; 95% CI, 2.00–18.17; P = 0.001) than those with low-USP-11–expressing tumors. Patients who did not achieve a pCR had an increased risk of recurrence (OR, 5.16; 95% CI, 1.16–23.07; P = 0.03). Conclusions Our data indicate that USP-11 is not a predictor of a pCR after anthracycline-taxane–containing NST for breast cancer. Low USP-11 expression was independently correlated with better survival outcomes." @default.
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• W1973243344 date "2013-01-01" @default.
• W1973243344 modified "2023-10-18" @default.
• W1973243344 title "USP-11 as a Predictive and Prognostic Factor Following Neoadjuvant Therapy in Women With Breast Cancer" @default.
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• W1973243344 doi "https://doi.org/10.1097/ppo.0b013e3182801b3a" @default.
• W1973243344 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3568679" @default.
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