FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973247259> ?p ?o ?g. }

• W1973247259 endingPage "927" @default.
• W1973247259 startingPage "922" @default.
• W1973247259 abstract "Of patients being treated by radiotherapy for cancer, a small proportion develop marked long-term radiation damage. It is believed that this is due, at least in part, to intrinsic individual differences in radiosensitivity, but the underlying mechanism is unknown. Individuals affected by the recessive disease ataxia telangiectasia (AT) exhibit extreme sensitivity to ionizing radiation. Cells from such individuals are also radiosensitive in in vitro assays, and cells from AT heterozygotes are reported to show in vitro radiosensitivity at an intermediate level between homozygotes and control subjects. In order to examine the possibility that a defect in the ATM gene may account for a proportion of radiotherapy complications, 41 breast cancer patients developing marked changes in breast appearance after radiotherapy and 39 control subjects who showed no clinically detectable reaction after radiotherapy were screened for mutations in the ATM gene. One out of 41 cases showing adverse reactions was heterozygous for a mutation (insertion A at NT 898) that is predicted to generate a truncated protein of 251 amino acids. No truncating mutations were detected in the control subjects. On the basis of this result, the estimated percentage (95% confidence interval) of AT heterozygous patients in radiosensitive cases was 2.4% (0.1-12.9%) and in control subjects (0-9.0%). We conclude that ATM gene defects are not the major cause of radiotherapy complications in women with breast cancer." @default.
• W1973247259 created "2016-06-24" @default.
• W1973247259 creator A5003212785 @default.
• W1973247259 creator A5004371634 @default.
• W1973247259 creator A5006665510 @default.
• W1973247259 creator A5011857990 @default.
• W1973247259 creator A5022949064 @default.
• W1973247259 creator A5024984449 @default.
• W1973247259 creator A5033149434 @default.
• W1973247259 creator A5042363092 @default.
• W1973247259 creator A5047548672 @default.
• W1973247259 creator A5067226323 @default.
• W1973247259 creator A5068651478 @default.
• W1973247259 creator A5068939137 @default.
• W1973247259 creator A5091418824 @default.
• W1973247259 date "1998-10-01" @default.
• W1973247259 modified "2023-10-10" @default.
• W1973247259 title "Heterozygosity for mutations in the ataxia telangiectasia gene is not a major cause of radiotherapy complications in breast cancer patients" @default.
• W1973247259 cites W1500755775 @default.
• W1973247259 cites W1984379214 @default.
• W1973247259 cites W1996044070 @default.
• W1973247259 cites W2022807956 @default.
• W1973247259 cites W2035154953 @default.
• W1973247259 cites W2036911210 @default.
• W1973247259 cites W2037355114 @default.
• W1973247259 cites W2052604214 @default.
• W1973247259 cites W2085252163 @default.
• W1973247259 cites W2090482621 @default.
• W1973247259 cites W2146693770 @default.
• W1973247259 cites W2153923420 @default.
• W1973247259 cites W2159168998 @default.
• W1973247259 cites W2291134929 @default.
• W1973247259 cites W2336992970 @default.
• W1973247259 cites W4290261080 @default.
• W1973247259 doi "https://doi.org/10.1038/bjc.1998.602" @default.
• W1973247259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2063134" @default.
• W1973247259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9764584" @default.
• W1973247259 hasPublicationYear "1998" @default.
• W1973247259 type Work @default.
• W1973247259 sameAs 1973247259 @default.
• W1973247259 citedByCount "60" @default.
• W1973247259 countsByYear W19732472592012 @default.
• W1973247259 countsByYear W19732472592014 @default.
• W1973247259 countsByYear W19732472592015 @default.
• W1973247259 countsByYear W19732472592016 @default.
• W1973247259 countsByYear W19732472592021 @default.
• W1973247259 crossrefType "journal-article" @default.
• W1973247259 hasAuthorship W1973247259A5003212785 @default.
• W1973247259 hasAuthorship W1973247259A5004371634 @default.
• W1973247259 hasAuthorship W1973247259A5006665510 @default.
• W1973247259 hasAuthorship W1973247259A5011857990 @default.
• W1973247259 hasAuthorship W1973247259A5022949064 @default.
• W1973247259 hasAuthorship W1973247259A5024984449 @default.
• W1973247259 hasAuthorship W1973247259A5033149434 @default.
• W1973247259 hasAuthorship W1973247259A5042363092 @default.
• W1973247259 hasAuthorship W1973247259A5047548672 @default.
• W1973247259 hasAuthorship W1973247259A5067226323 @default.
• W1973247259 hasAuthorship W1973247259A5068651478 @default.
• W1973247259 hasAuthorship W1973247259A5068939137 @default.
• W1973247259 hasAuthorship W1973247259A5091418824 @default.
• W1973247259 hasBestOaLocation W19732472591 @default.
• W1973247259 hasConcept C104317684 @default.
• W1973247259 hasConcept C111337013 @default.
• W1973247259 hasConcept C121332964 @default.
• W1973247259 hasConcept C121608353 @default.
• W1973247259 hasConcept C126322002 @default.
• W1973247259 hasConcept C135763542 @default.
• W1973247259 hasConcept C142724271 @default.
• W1973247259 hasConcept C143425029 @default.
• W1973247259 hasConcept C143589142 @default.
• W1973247259 hasConcept C143998085 @default.
• W1973247259 hasConcept C153471976 @default.
• W1973247259 hasConcept C180754005 @default.
• W1973247259 hasConcept C185544564 @default.
• W1973247259 hasConcept C206684579 @default.
• W1973247259 hasConcept C26114605 @default.
• W1973247259 hasConcept C2776330896 @default.
• W1973247259 hasConcept C2779486608 @default.
• W1973247259 hasConcept C501734568 @default.
• W1973247259 hasConcept C502942594 @default.
• W1973247259 hasConcept C509974204 @default.
• W1973247259 hasConcept C530470458 @default.
• W1973247259 hasConcept C54355233 @default.
• W1973247259 hasConcept C552990157 @default.
• W1973247259 hasConcept C71924100 @default.
• W1973247259 hasConcept C86803240 @default.
• W1973247259 hasConceptScore W1973247259C104317684 @default.
• W1973247259 hasConceptScore W1973247259C111337013 @default.
• W1973247259 hasConceptScore W1973247259C121332964 @default.
• W1973247259 hasConceptScore W1973247259C121608353 @default.
• W1973247259 hasConceptScore W1973247259C126322002 @default.
• W1973247259 hasConceptScore W1973247259C135763542 @default.
• W1973247259 hasConceptScore W1973247259C142724271 @default.
• W1973247259 hasConceptScore W1973247259C143425029 @default.
• W1973247259 hasConceptScore W1973247259C143589142 @default.
• W1973247259 hasConceptScore W1973247259C143998085 @default.
• W1973247259 hasConceptScore W1973247259C153471976 @default.
• W1973247259 hasConceptScore W1973247259C180754005 @default.

• next