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• W1973247745 abstract "Purpose To develop, implement, and evaluate a novel postprocessing method for enhancing the spectral resolution of in vivo MR spectroscopic imaging (MRSI) data. Materials and Methods Magnetic field inhomogeneity across the imaging volume was determined by acquiring MRI datasets with two differing echo times. The lineshapes of the MRSI spectra were derived from these field maps by simulating an MRSI scan of a virtual sample whose resonance frequencies varied according to the observed variations in the magnetic field. By deconvolving the lineshapes from the measured MRSI spectra, the linebroadening effects of the field inhomogeneities were reduced significantly. Results Both phantom and in vivo proton MRSI spectra exhibited significantly enhanced spectral resolutions and improved spectral lineshapes following application of our method. Quantitative studies on a phantom show that, on average, the full width at half maximum of water peaks was reduced 42%, the full width at tenth maximum was reduced 38%, and the asymmetries of the peaks were reduced 86%. Conclusion Our method reduces the linebroadening and lineshape distortions caused by magnetic field inhomogeneities. It substantially improves the spectral resolution and lineshape of MRSI data. J. Magn. Reson. Imaging 2009;29:1395–1405. © 2009 Wiley-Liss, Inc." @default.
• W1973247745 created "2016-06-24" @default.
• W1973247745 creator A5061363473 @default.
• W1973247745 creator A5061929421 @default.
• W1973247745 date "2009-06-01" @default.
• W1973247745 modified "2023-09-25" @default.
• W1973247745 title "Spectral resolution amelioration by deconvolution (SPREAD) in MR spectroscopic imaging" @default.
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• W1973247745 doi "https://doi.org/10.1002/jmri.21784" @default.
• W1973247745 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2762796" @default.
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