Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973252291> ?p ?o ?g. }
- W1973252291 endingPage "572" @default.
- W1973252291 startingPage "566" @default.
- W1973252291 abstract "Ovarian failure is a-known side-effect observed in women treated for cancer. Doxorubicin (DXR) was found to be detrimental to MII mouse oocytes. We aimed at characterizing the effect of DXR on germinal vesicle (GV) oocytes that comprise the majority of oocytes within ovaries encountering chemotherapy. Mouse follicles and oocytes were exposed to DXR in vitro. DXR localization and its possible cellular targets were examined by fluorescence confocal microscopy. We demonstrated that DXR crosses the blood–follicle barrier and accumulates in oocytes and granulosa cells. The mechanism of DXR-induced apoptosis involves chromosomal disintegration, activation of the mitochondria followed by activation of PERK and caspase-12 and inactivation of PARP. The follicular GV oocytes were more vulnerable to the toxic effect of DXR than ovulated MII oocytes. We suggest that DXR elicits apoptotic signal within GV oocytes that involves activation of the mitochondria, induction of ER-stress and a possible increase in intracellular calcium." @default.
- W1973252291 created "2016-06-24" @default.
- W1973252291 creator A5007458418 @default.
- W1973252291 creator A5012814827 @default.
- W1973252291 creator A5049515745 @default.
- W1973252291 creator A5057005436 @default.
- W1973252291 creator A5072457386 @default.
- W1973252291 creator A5077499704 @default.
- W1973252291 date "2010-12-01" @default.
- W1973252291 modified "2023-10-02" @default.
- W1973252291 title "Doxorubicin-induced apoptosis in germinal vesicle (GV) oocytes☆" @default.
- W1973252291 cites W1559184092 @default.
- W1973252291 cites W1607531254 @default.
- W1973252291 cites W1784820495 @default.
- W1973252291 cites W1791262955 @default.
- W1973252291 cites W1964179489 @default.
- W1973252291 cites W1978928320 @default.
- W1973252291 cites W1981531462 @default.
- W1973252291 cites W1982487922 @default.
- W1973252291 cites W1984046196 @default.
- W1973252291 cites W1989185728 @default.
- W1973252291 cites W1991487627 @default.
- W1973252291 cites W1992915927 @default.
- W1973252291 cites W1993387279 @default.
- W1973252291 cites W1994913349 @default.
- W1973252291 cites W1995099027 @default.
- W1973252291 cites W1995301389 @default.
- W1973252291 cites W2000233149 @default.
- W1973252291 cites W2001178179 @default.
- W1973252291 cites W2006334817 @default.
- W1973252291 cites W2014063249 @default.
- W1973252291 cites W2014755491 @default.
- W1973252291 cites W2025639524 @default.
- W1973252291 cites W2028971323 @default.
- W1973252291 cites W2030261740 @default.
- W1973252291 cites W2034730235 @default.
- W1973252291 cites W2038916833 @default.
- W1973252291 cites W2039444414 @default.
- W1973252291 cites W2059487482 @default.
- W1973252291 cites W2066023275 @default.
- W1973252291 cites W2066429786 @default.
- W1973252291 cites W2070005495 @default.
- W1973252291 cites W2072140679 @default.
- W1973252291 cites W2084461771 @default.
- W1973252291 cites W2084609653 @default.
- W1973252291 cites W2087402783 @default.
- W1973252291 cites W2094074801 @default.
- W1973252291 cites W2104685967 @default.
- W1973252291 cites W2106926141 @default.
- W1973252291 cites W2109460496 @default.
- W1973252291 cites W2124545837 @default.
- W1973252291 cites W2127479913 @default.
- W1973252291 cites W2129807379 @default.
- W1973252291 cites W2134158036 @default.
- W1973252291 cites W2134295452 @default.
- W1973252291 cites W2135215861 @default.
- W1973252291 cites W2139777504 @default.
- W1973252291 cites W2147551208 @default.
- W1973252291 cites W2147555665 @default.
- W1973252291 cites W2154229994 @default.
- W1973252291 cites W2156483686 @default.
- W1973252291 cites W2164047272 @default.
- W1973252291 cites W2165064047 @default.
- W1973252291 cites W2165681130 @default.
- W1973252291 cites W2285784546 @default.
- W1973252291 cites W295172491 @default.
- W1973252291 cites W2157324551 @default.
- W1973252291 cites W386199117 @default.
- W1973252291 doi "https://doi.org/10.1016/j.reprotox.2010.07.003" @default.
- W1973252291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20656019" @default.
- W1973252291 hasPublicationYear "2010" @default.
- W1973252291 type Work @default.
- W1973252291 sameAs 1973252291 @default.
- W1973252291 citedByCount "80" @default.
- W1973252291 countsByYear W19732522912012 @default.
- W1973252291 countsByYear W19732522912013 @default.
- W1973252291 countsByYear W19732522912014 @default.
- W1973252291 countsByYear W19732522912015 @default.
- W1973252291 countsByYear W19732522912016 @default.
- W1973252291 countsByYear W19732522912017 @default.
- W1973252291 countsByYear W19732522912018 @default.
- W1973252291 countsByYear W19732522912019 @default.
- W1973252291 countsByYear W19732522912020 @default.
- W1973252291 countsByYear W19732522912021 @default.
- W1973252291 countsByYear W19732522912022 @default.
- W1973252291 countsByYear W19732522912023 @default.
- W1973252291 crossrefType "journal-article" @default.
- W1973252291 hasAuthorship W1973252291A5007458418 @default.
- W1973252291 hasAuthorship W1973252291A5012814827 @default.
- W1973252291 hasAuthorship W1973252291A5049515745 @default.
- W1973252291 hasAuthorship W1973252291A5057005436 @default.
- W1973252291 hasAuthorship W1973252291A5072457386 @default.
- W1973252291 hasAuthorship W1973252291A5077499704 @default.
- W1973252291 hasConcept C126322002 @default.
- W1973252291 hasConcept C134018914 @default.
- W1973252291 hasConcept C16685009 @default.
- W1973252291 hasConcept C185592680 @default.
- W1973252291 hasConcept C187785154 @default.