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• W1973253452 abstract "The membrane protein composition of the primary cilium, a key sensory organelle, is dynamically regulated during cilium-generated signaling [1Hildebrandt F. Benzing T. Katsanis N. Ciliopathies.N. Engl. J. Med. 2011; 364: 1533-1543Crossref PubMed Scopus (969) Google Scholar, 2Drummond I.A. Cilia functions in development.Curr. Opin. Cell Biol. 2012; 24: 24-30Crossref PubMed Scopus (86) Google Scholar]. During ciliogenesis, ciliary membrane proteins, along with structural and signaling proteins, are carried through the multicomponent, intensely studied ciliary diffusion barrier at the base of the organelle [3Craige B. Tsao C.C. Diener D.R. Hou Y. Lechtreck K.F. Rosenbaum J.L. Witman G.B. CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content.J. Cell Biol. 2010; 190: 927-940Crossref PubMed Scopus (286) Google Scholar, 4Sang L. Miller J.J. Corbit K.C. Giles R.H. Brauer M.J. Otto E.A. Baye L.M. Wen X. Scales S.J. Kwong M. et al.Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.Cell. 2011; 145: 513-528Abstract Full Text Full Text PDF PubMed Scopus (438) Google Scholar, 5Chih B. Liu P. Chinn Y. Chalouni C. Komuves L.G. Hass P.E. Sandoval W. Peterson A.S. A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.Nat. Cell Biol. 2012; 14: 61-72Crossref Scopus (251) Google Scholar, 6Garcia-Gonzalo F.R. Corbit K.C. Sirerol-Piquer M.S. Ramaswami G. Otto E.A. Noriega T.R. Seol A.D. Robinson J.F. Bennett C.L. Josifova D.J. et al.A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.Nat. Genet. 2011; 43: 776-784Crossref PubMed Scopus (450) Google Scholar, 7Hu Q. Milenkovic L. Jin H. Scott M.P. Nachury M.V. Spiliotis E.T. Nelson W.J. A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution.Science. 2010; 329: 436-439Crossref PubMed Scopus (369) Google Scholar, 8Emmer B.T. Maric D. Engman D.M. Molecular mechanisms of protein and lipid targeting to ciliary membranes.J. Cell Sci. 2010; 123: 529-536Crossref PubMed Scopus (104) Google Scholar] by intraflagellar transport (IFT) [9Nachury M.V. Seeley E.S. Jin H. Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier?.Annu. Rev. Cell Dev. Biol. 2010; 26: 59-87Crossref PubMed Scopus (324) Google Scholar, 10Scholey J.M. Intraflagellar transport motors in cilia: moving along the cell’s antenna.J. Cell Biol. 2008; 180: 23-29Crossref PubMed Scopus (209) Google Scholar, 11Hao L. Thein M. Brust-Mascher I. Civelekoglu-Scholey G. Lu Y. Acar S. Prevo B. Shaham S. Scholey J.M. Intraflagellar transport delivers tubulin isotypes to sensory cilium middle and distal segments.Nat. Cell Biol. 2011; 13: 790-798Crossref PubMed Scopus (123) Google Scholar, 12Rohatgi R. Snell W.J. The ciliary membrane.Curr. Opin. Cell Biol. 2010; 22: 541-546Crossref PubMed Scopus (125) Google Scholar, 13Huang K. Diener D.R. Mitchell A. Pazour G.J. Witman G.B. Rosenbaum J.L. Function and dynamics of PKD2 in Chlamydomonas reinhardtii flagella.J. Cell Biol. 2007; 179: 501-514Crossref PubMed Scopus (139) Google Scholar, 14Qin H. Burnette D.T. Bae Y.K. Forscher P. Barr M.M. Rosenbaum J.L. Intraflagellar transport is required for the vectorial movement of TRPV channels in the ciliary membrane.Curr. Biol. 2005; 15: 1695-1699Abstract Full Text Full Text PDF PubMed Scopus (151) Google Scholar, 15Trivedi D. Colin E. Louie C.M. Williams D.S. Live-cell imaging evidence for the ciliary transport of rod photoreceptor opsin by heterotrimeric kinesin-2.J. Neurosci. 2012; 32: 10587-10593Crossref PubMed Scopus (55) Google Scholar, 16Keady B.T. Samtani R. Tobita K. Tsuchya M. San Agustin J.T. Follit J.A. Jonassen J.A. Subramanian R. Lo C.W. Pazour G.J. IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport.Dev. Cell. 2012; 22: 940-951Abstract Full Text Full Text PDF PubMed Scopus (155) Google Scholar, 17Follit J.A. Tuft R.A. Fogarty K.E. Pazour G.J. The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly.Mol. Biol. Cell. 2006; 17: 3781-3792Crossref PubMed Scopus (381) Google Scholar, 18Mukhopadhyay S. Wen X. Chih B. Nelson C.D. Lane W.S. Scales S.J. Jackson P.K. TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.Genes Dev. 2010; 24: 2180-2193Crossref PubMed Scopus (266) Google Scholar]. A favored model is that signaling-triggered accumulation of previously excluded membrane proteins in fully formed cilia [19Ocbina P.J. Eggenschwiler J.T. Moskowitz I. Anderson K.V. Complex interactions between genes controlling trafficking in primary cilia.Nat. Genet. 2011; 43: 547-553Crossref PubMed Scopus (145) Google Scholar, 20Kim J. Kato M. Beachy P.A. Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus.Proc. Natl. Acad. Sci. USA. 2009; 106: 21666-21671Crossref PubMed Scopus (252) Google Scholar, 21Rohatgi R. Milenkovic L. Scott M.P. Patched1 regulates hedgehog signaling at the primary cilium.Science. 2007; 317: 372-376Crossref PubMed Scopus (1056) Google Scholar] also requires IFT, but direct evidence is lacking. Here, in studies of regulated entry of a membrane protein into the flagellum of Chlamydomonas, we show that cells use an IFT-independent mechanism to breach the diffusion barrier at the flagellar base. In resting cells, a flagellar signaling component [22Snell W.J. Goodenough U.W. Flagellar adhesion, flagellar-generated signaling, and gamete fusion during mating.in: Second Edition. The Chlamydomonas Sourcebook. Volume 3. Elsevier, New York2009: 369-394Google Scholar], the integral membrane polypeptide SAG1-C65, is uniformly distributed over the plasma membrane and excluded from the flagellar membrane. Flagellar adhesion-induced signaling triggers rapid, striking redistribution of the protein to the apical ends of the cells concomitantly with entry into the flagella. Protein polarization and flagellar enrichment are facilitated by cytoplasmic microtubules. Using a conditional anterograde IFT mutant, we demonstrate that the IFT machinery is not required for regulated SAG1-C65 entry into flagella. Thus, integral membrane proteins can negotiate passage through the ciliary diffusion barrier without the need for a motor." @default.
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• W1973253452 title "Regulated Membrane Protein Entry into Flagella Is Facilitated by Cytoplasmic Microtubules and Does Not Require IFT" @default.
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• W1973253452 doi "https://doi.org/10.1016/j.cub.2013.06.025" @default.
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