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• W1973257737 abstract "Abstract Background : In the process of apoptosis, it is known that the transition of cytochrome c from mitochondria into the cytosol occurs, and tumor necrosis factor (TNF)‐α is one of the molecules responsible for this event. But in the state of hypercytokine induced by d ‐galactosamine (D‐GaIN)/Lipopolysaccharide (LPS), the localization of cytochrome c is little known. Methods : Rats were administrated with D‐GaIN(700 mg/kg)/LPS(200 µg/kg). Blood and tissue samples were collected and examined for levels of pro‐inflammatory cytokines, the apoptosis of liver cells, and the localization of cytochrome c . Result : Before administration of D‐GaIN/LPS, cytochrome c was definitely localized in the mitochondria. At 2 h after simultaneous administration of D‐GaIN/LPS, cytochrome c had accumulated in the cytosol following abrupt increases of plasma TNF‐α. Massive cell destruction due to apoptosis proved by Terminal deoxynucleo­tidyl transferase‐mediated dUTP nick end labeling staining was observed in liver tissue 4 h later and markedly increased levels of cytochrome c were detected in the plasma 12 h after D‐GaIN/LPS administration. Conclusion : Liver injury induced by simultaneous administration of D‐GaIN/LPS was closely associated with the production of TNF‐α, and also with the dynamic movement of cytochrome c from the mitochondria into the cytosol, and then into the systemic circulation. The detection of plasma cytochrome c levels may be a useful clinical tool for the detection of apoptosis in vivo ." @default.
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• W1973257737 date "2004-12-01" @default.
• W1973257737 modified "2023-10-10" @default.
• W1973257737 title "Dynamic movement of cytochrome<i>c</i>from mitochondria into cytosol and peripheral circulation in massive hepatic cell injury" @default.
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• W1973257737 doi "https://doi.org/10.1111/j.1442-200x.2004.01980.x" @default.
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