FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973260699> ?p ?o ?g. }

• W1973260699 endingPage "1017" @default.
• W1973260699 startingPage "1010" @default.
• W1973260699 abstract "Abstract Background: The authors studied whether neonatal propofol anesthesia affects development of the endocrine and neural systems. Methods: Sprague–Dawley rats were anesthetized using intraperitoneal propofol for 5 h on postnatal days (P) 4, 5, or 6. Pups that received either saline or intralipid, but not those in the negative control groups, were also maternally separated for 5 h. Serum levels of corticosterone were measured immediately after anesthesia and in adulthood after prepulse inhibition of acoustic startle testing (≥P80), followed by measurement of hippocampal neuronal activity. Results: Propofol acutely increased corticosterone levels to 146.6 ± 23.5 ng/ml (n = 6) versus 16.4 ± 3.5 ng/ml (n = 6) and 18.4 ± 3.2 ng/ml (n = 6) in saline- and intralipd-treated pups, respectively. In adulthood, the propofol group exhibited exacerbated endocrine responses to stress in a form of increased corticosterone levels (1,171.58 ± 149.17 ng/ml [n = 15] vs. 370.02 ± 36.01 ng/ml [n = 10] in the saline group). The propofol group had increased the frequency of miniature inhibitory postsynaptic currents in CA1 neurons of male and female rats, but reduced prepulse inhibition of startle was detected only in males. The Na+–K+–2Cl− cotransporter inhibitor bumetanide, administered to pups before propofol injection, alleviated long-term endocrine and prepulse inhibition abnormalities. Exogenous corticosterone, administered to naive pups, induced synaptic and endocrine but not prepulse inhibition effects, similar to those of propofol. Conclusion: Propofol-caused acute increases in corticosterone levels and γ-aminobutyric acid type A receptor–mediated excitation at the time of anesthesia may play mechanistic roles in development of exacerbated endocrine responses to stress and neurobehavioral abnormalities." @default.
• W1973260699 created "2016-06-24" @default.
• W1973260699 creator A5004651591 @default.
• W1973260699 creator A5004807635 @default.
• W1973260699 creator A5031379605 @default.
• W1973260699 creator A5053955596 @default.
• W1973260699 creator A5055142389 @default.
• W1973260699 creator A5071267054 @default.
• W1973260699 creator A5073155596 @default.
• W1973260699 creator A5088697575 @default.
• W1973260699 date "2014-11-01" @default.
• W1973260699 modified "2023-10-18" @default.
• W1973260699 title "Endocrine and Neurobehavioral Abnormalities Induced by Propofol Administered to Neonatal Rats" @default.
• W1973260699 cites W1974074735 @default.
• W1973260699 cites W1974879622 @default.
• W1973260699 cites W1975109243 @default.
• W1973260699 cites W1977249405 @default.
• W1973260699 cites W1984444802 @default.
• W1973260699 cites W1988059569 @default.
• W1973260699 cites W2005677383 @default.
• W1973260699 cites W2008994881 @default.
• W1973260699 cites W2015629767 @default.
• W1973260699 cites W2015701831 @default.
• W1973260699 cites W2018696822 @default.
• W1973260699 cites W2021231536 @default.
• W1973260699 cites W2024469079 @default.
• W1973260699 cites W2041144442 @default.
• W1973260699 cites W2046960533 @default.
• W1973260699 cites W2049482242 @default.
• W1973260699 cites W2052128699 @default.
• W1973260699 cites W2056768120 @default.
• W1973260699 cites W2062472783 @default.
• W1973260699 cites W2064910482 @default.
• W1973260699 cites W2073626127 @default.
• W1973260699 cites W2074141888 @default.
• W1973260699 cites W2078509003 @default.
• W1973260699 cites W2085208310 @default.
• W1973260699 cites W2087235914 @default.
• W1973260699 cites W2087826027 @default.
• W1973260699 cites W2096981089 @default.
• W1973260699 cites W2099201877 @default.
• W1973260699 cites W2100231995 @default.
• W1973260699 cites W2101187510 @default.
• W1973260699 cites W2110887814 @default.
• W1973260699 cites W2112686543 @default.
• W1973260699 cites W2139075903 @default.
• W1973260699 cites W2150131651 @default.
• W1973260699 cites W2153522818 @default.
• W1973260699 doi "https://doi.org/10.1097/aln.0000000000000366" @default.
• W1973260699 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4206572" @default.
• W1973260699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24992523" @default.
• W1973260699 hasPublicationYear "2014" @default.
• W1973260699 type Work @default.
• W1973260699 sameAs 1973260699 @default.
• W1973260699 citedByCount "34" @default.
• W1973260699 countsByYear W19732606992015 @default.
• W1973260699 countsByYear W19732606992016 @default.
• W1973260699 countsByYear W19732606992017 @default.
• W1973260699 countsByYear W19732606992018 @default.
• W1973260699 countsByYear W19732606992019 @default.
• W1973260699 countsByYear W19732606992020 @default.
• W1973260699 countsByYear W19732606992021 @default.
• W1973260699 countsByYear W19732606992022 @default.
• W1973260699 countsByYear W19732606992023 @default.
• W1973260699 crossrefType "journal-article" @default.
• W1973260699 hasAuthorship W1973260699A5004651591 @default.
• W1973260699 hasAuthorship W1973260699A5004807635 @default.
• W1973260699 hasAuthorship W1973260699A5031379605 @default.
• W1973260699 hasAuthorship W1973260699A5053955596 @default.
• W1973260699 hasAuthorship W1973260699A5055142389 @default.
• W1973260699 hasAuthorship W1973260699A5071267054 @default.
• W1973260699 hasAuthorship W1973260699A5073155596 @default.
• W1973260699 hasAuthorship W1973260699A5088697575 @default.
• W1973260699 hasBestOaLocation W19732606991 @default.
• W1973260699 hasConcept C118552586 @default.
• W1973260699 hasConcept C126322002 @default.
• W1973260699 hasConcept C134018914 @default.
• W1973260699 hasConcept C141421786 @default.
• W1973260699 hasConcept C2776277131 @default.
• W1973260699 hasConcept C2776412080 @default.
• W1973260699 hasConcept C2777397205 @default.
• W1973260699 hasConcept C2780352252 @default.
• W1973260699 hasConcept C42219234 @default.
• W1973260699 hasConcept C46699223 @default.
• W1973260699 hasConcept C71315377 @default.
• W1973260699 hasConcept C71924100 @default.
• W1973260699 hasConceptScore W1973260699C118552586 @default.
• W1973260699 hasConceptScore W1973260699C126322002 @default.
• W1973260699 hasConceptScore W1973260699C134018914 @default.
• W1973260699 hasConceptScore W1973260699C141421786 @default.
• W1973260699 hasConceptScore W1973260699C2776277131 @default.
• W1973260699 hasConceptScore W1973260699C2776412080 @default.
• W1973260699 hasConceptScore W1973260699C2777397205 @default.
• W1973260699 hasConceptScore W1973260699C2780352252 @default.
• W1973260699 hasConceptScore W1973260699C42219234 @default.
• W1973260699 hasConceptScore W1973260699C46699223 @default.
• W1973260699 hasConceptScore W1973260699C71315377 @default.
• W1973260699 hasConceptScore W1973260699C71924100 @default.

• next