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- W1973270931 abstract "To decrease virulence, we deleted the E3L gene, which is required for interferon-resistance and virulence, and replaced it with a gene from Ambystoma tigrinum virus (ATV, the new virus is NYVAC-C+12-ATV), which restores a single round of replication. Results In vitro characterization of the constructs demonstrates restoration of replication in primary and human cell lines. NYVAC-C+12-ATV leads to induction of pro-inflammatory signal transduction pathways. Pathogenicity studies in newborn mice demonstrate attenuation of 3–5 logs when compared to wt vaccinia virus or to NYCBH." @default.
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- W1973270931 date "2009-10-01" @default.
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- W1973270931 title "OA021-01. Construction and characterization of replication competent attenuated NYVAC-based vectors as potential HIV vaccines" @default.
- W1973270931 doi "https://doi.org/10.1186/1742-4690-6-s3-o13" @default.
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