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- W1973273887 abstract "In HeLa S3 cultures, theophylline even after 24 hours scarcely increased basal cAMP levels although it is an effective inhibitor of HeLa phosphodiesterases in vitro as well as in intact cells. The persistance of cAMP in concentrated homogenates incubated at 0° or 25°, and its resistance to charcoal adsorption suggest that it is protected from PDE by being strongly bound to specific proteins. In contrast to HeLa cultures, Ehrlich ascites carcinoma (EAC) cells do respond to theophylline by a rapid increase in cAMP. On incubation of EAC homogenates, free cAMP is degraded while the bound cAMP fraction again is protected. The existence of two cAMP pools - free cAMP and protein-bound cAMP - in tissues is postulated. They are not in (rapid) equilibrium with each other, and they differ in turnover rates." @default.
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- W1973273887 date "1975-05-01" @default.
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- W1973273887 title "Basal cAMP in HeLa cells is protected from phosphodiesterase and does not turn over" @default.
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- W1973273887 doi "https://doi.org/10.1016/0006-291x(75)90352-6" @default.
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