Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973285887> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1973285887 endingPage "155" @default.
- W1973285887 startingPage "143" @default.
- W1973285887 abstract "We consider the problem of separating the direct effects of an exposure from effects relayed through an intermediate variable (indirect effects). We show that adjustment for the intermediate variable, which is the most common method of estimating direct effects, can be biased. We also show that even in a randomized crossover trial of exposure, direct and indirect effects cannot be separated without special assumptions; in other words, direct and indirect effects are not separately identifiable when only exposure is randomized. If the exposure and intermediate never interact to cause disease and if intermediate effects can be controlled, that is, blocked by a suitable intervention, then a trial randomizing both exposure and the intervention can separate direct from indirect effects. Nonetheless, the estimation must be carried out using the G-computation algorithm. Conventional adjustment methods remain biased. When exposure and the intermediate interact to cause disease, direct and indirect effects will not be separable even in a trial in which both the exposure and the intervention blocking intermediate effects are randomly assigned. Nonetheless, in such a trial, one can still estimate the fraction of exposure-induced disease that could be prevented by control of the intermediate. Even in the absence of an intervention blocking the intermediate effect, the fraction of exposure-induced disease that could be prevented by control of the intermediate can be estimated with the G-computation algorithm if data are obtained on additional confounding variables." @default.
- W1973285887 created "2016-06-24" @default.
- W1973285887 creator A5005273634 @default.
- W1973285887 creator A5079863455 @default.
- W1973285887 date "1992-03-01" @default.
- W1973285887 modified "2023-10-17" @default.
- W1973285887 title "Identifiability and Exchangeability for Direct and Indirect Effects" @default.
- W1973285887 cites W1927040111 @default.
- W1973285887 cites W1968807808 @default.
- W1973285887 cites W2005759326 @default.
- W1973285887 cites W2035142205 @default.
- W1973285887 cites W2064790857 @default.
- W1973285887 cites W2068434797 @default.
- W1973285887 cites W2082299845 @default.
- W1973285887 cites W2167912640 @default.
- W1973285887 cites W2169619449 @default.
- W1973285887 doi "https://doi.org/10.1097/00001648-199203000-00013" @default.
- W1973285887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1576220" @default.
- W1973285887 hasPublicationYear "1992" @default.
- W1973285887 type Work @default.
- W1973285887 sameAs 1973285887 @default.
- W1973285887 citedByCount "1386" @default.
- W1973285887 countsByYear W19732858872012 @default.
- W1973285887 countsByYear W19732858872013 @default.
- W1973285887 countsByYear W19732858872014 @default.
- W1973285887 countsByYear W19732858872015 @default.
- W1973285887 countsByYear W19732858872016 @default.
- W1973285887 countsByYear W19732858872017 @default.
- W1973285887 countsByYear W19732858872018 @default.
- W1973285887 countsByYear W19732858872019 @default.
- W1973285887 countsByYear W19732858872020 @default.
- W1973285887 countsByYear W19732858872021 @default.
- W1973285887 countsByYear W19732858872022 @default.
- W1973285887 countsByYear W19732858872023 @default.
- W1973285887 crossrefType "journal-article" @default.
- W1973285887 hasAuthorship W1973285887A5005273634 @default.
- W1973285887 hasAuthorship W1973285887A5079863455 @default.
- W1973285887 hasBestOaLocation W19732858871 @default.
- W1973285887 hasConcept C105795698 @default.
- W1973285887 hasConcept C122770356 @default.
- W1973285887 hasConcept C144745244 @default.
- W1973285887 hasConcept C149629883 @default.
- W1973285887 hasConcept C149782125 @default.
- W1973285887 hasConcept C158600405 @default.
- W1973285887 hasConcept C162144332 @default.
- W1973285887 hasConcept C17744445 @default.
- W1973285887 hasConcept C178790620 @default.
- W1973285887 hasConcept C185592680 @default.
- W1973285887 hasConcept C199539241 @default.
- W1973285887 hasConcept C2780836151 @default.
- W1973285887 hasConcept C33923547 @default.
- W1973285887 hasConcept C77350462 @default.
- W1973285887 hasConceptScore W1973285887C105795698 @default.
- W1973285887 hasConceptScore W1973285887C122770356 @default.
- W1973285887 hasConceptScore W1973285887C144745244 @default.
- W1973285887 hasConceptScore W1973285887C149629883 @default.
- W1973285887 hasConceptScore W1973285887C149782125 @default.
- W1973285887 hasConceptScore W1973285887C158600405 @default.
- W1973285887 hasConceptScore W1973285887C162144332 @default.
- W1973285887 hasConceptScore W1973285887C17744445 @default.
- W1973285887 hasConceptScore W1973285887C178790620 @default.
- W1973285887 hasConceptScore W1973285887C185592680 @default.
- W1973285887 hasConceptScore W1973285887C199539241 @default.
- W1973285887 hasConceptScore W1973285887C2780836151 @default.
- W1973285887 hasConceptScore W1973285887C33923547 @default.
- W1973285887 hasConceptScore W1973285887C77350462 @default.
- W1973285887 hasIssue "2" @default.
- W1973285887 hasLocation W19732858871 @default.
- W1973285887 hasLocation W19732858872 @default.
- W1973285887 hasOpenAccess W1973285887 @default.
- W1973285887 hasPrimaryLocation W19732858871 @default.
- W1973285887 hasRelatedWork W1847771980 @default.
- W1973285887 hasRelatedWork W1973285887 @default.
- W1973285887 hasRelatedWork W2111735528 @default.
- W1973285887 hasRelatedWork W2791540175 @default.
- W1973285887 hasRelatedWork W2886512889 @default.
- W1973285887 hasRelatedWork W2912000537 @default.
- W1973285887 hasRelatedWork W3093810250 @default.
- W1973285887 hasRelatedWork W3157098544 @default.
- W1973285887 hasRelatedWork W3176582836 @default.
- W1973285887 hasRelatedWork W338859419 @default.
- W1973285887 hasVolume "3" @default.
- W1973285887 isParatext "false" @default.
- W1973285887 isRetracted "false" @default.
- W1973285887 magId "1973285887" @default.
- W1973285887 workType "article" @default.