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• W1973286534 abstract "A group of 2-substituted pyrimido[4,5-b][1,4]benzothiazines were designed, synthesized, and evaluated as potential inhibitors of 15-lipoxygenase (15-LO). Compounds 4d and 4e showed the best IC50 of 15-LO inhibition (IC50 = 18 and 34 μM, respectively). All compounds were docked into 15-LO. As a result the sulfur atom was oriented toward the iron atom of the active site of 15-LO. We suggest the interaction of the iron atom is essential for the activity of the inhibitors." @default.
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• W1973286534 date "2007-03-01" @default.
• W1973286534 modified "2023-09-27" @default.
• W1973286534 title "Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors" @default.
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• W1973286534 doi "https://doi.org/10.1016/j.bmc.2006.12.022" @default.
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