FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973288013> ?p ?o ?g. }

• W1973288013 endingPage "507" @default.
• W1973288013 startingPage "500" @default.
• W1973288013 abstract "Abstract Previous reports have implicated the tumor necrosis factor ( TNF − 308 ) locus to non‐Hodgkin's lymphoma (NHL) outcome. The purpose of the study was to examine other chromosome components of the HLA 8.1 ancestral haplotype (AH) and their relation to the clinical course of NHL. HLA class I, II, TNF − 308 , and lymphotoxin alpha ( LTA +252 ) alleles were analyzed in 154 newly diagnosed NHL patients. Three locus haplotypes were inferred from the unphased genotypes by a Bayesian implementation of the expectation maximization (EM) algorithm using the PHASE 2.1 program. TNF − 308A was the only allele associated with fever, poor performance status, elevated β2‐microglobulin, TNF and its p75 receptor plasma levels. Although TNF − 308A was in strong linkage disequilibrium with the remaining alleles of 8.1 AH, only HLA‐ A*01 and HLA‐ B*08 showed association with prognostic variables. A part of 8.1 AH ( A*01‐B*08 ‐ TNF − 308A ) was predictive for shorter freedom from progression and overall survival (RR = 2.47, P = 0.041; RR = 3.15; P = 0.0049), an association that was stronger than TNF − 308A alone and independent from International Prognostic Index (RR = 1.55, P < 0.001; RR = 2.36; P < 0.0001). A*01 ‐ B*08 ‐ TNF − 308A fragment of 8.1AH remained an independent predictive factor in a multivariate model. We conclude that 8.1 AH is an important contributor to NHL outcome. In contrast to A*01‐B*08‐TNF − 308A , the remaining alleles ( Cw*07 , DRB1*03 , LTA +252G ) associated with the 8.1 AH seem to be its passive components. © 2007 Wiley‐Liss, Inc." @default.
• W1973288013 created "2016-06-24" @default.
• W1973288013 creator A5002475405 @default.
• W1973288013 creator A5003105021 @default.
• W1973288013 creator A5019711205 @default.
• W1973288013 creator A5044228973 @default.
• W1973288013 creator A5061408064 @default.
• W1973288013 creator A5065033706 @default.
• W1973288013 creator A5073907665 @default.
• W1973288013 creator A5077315723 @default.
• W1973288013 creator A5086354986 @default.
• W1973288013 creator A5088183144 @default.
• W1973288013 date "2007-03-02" @default.
• W1973288013 modified "2023-10-15" @default.
• W1973288013 title "Association of human leukocyte antigen ancestral haplotype 8.1 with adverse outcome of non-Hodgkin's lymphoma" @default.
• W1973288013 cites W1536565709 @default.
• W1973288013 cites W1583791807 @default.
• W1973288013 cites W1913222118 @default.
• W1973288013 cites W1976678451 @default.
• W1973288013 cites W1981988641 @default.
• W1973288013 cites W1992256266 @default.
• W1973288013 cites W2011204584 @default.
• W1973288013 cites W2011555335 @default.
• W1973288013 cites W2016864754 @default.
• W1973288013 cites W2033441738 @default.
• W1973288013 cites W2041955601 @default.
• W1973288013 cites W2042994132 @default.
• W1973288013 cites W2045605452 @default.
• W1973288013 cites W2083878136 @default.
• W1973288013 cites W2112519281 @default.
• W1973288013 cites W2119083333 @default.
• W1973288013 cites W2122019520 @default.
• W1973288013 cites W2126027842 @default.
• W1973288013 cites W2130943712 @default.
• W1973288013 cites W2132598458 @default.
• W1973288013 cites W2134193741 @default.
• W1973288013 cites W2150382709 @default.
• W1973288013 cites W2156588547 @default.
• W1973288013 cites W2158957674 @default.
• W1973288013 cites W2159487337 @default.
• W1973288013 cites W2165886134 @default.
• W1973288013 cites W2401837659 @default.
• W1973288013 cites W4205736005 @default.
• W1973288013 doi "https://doi.org/10.1002/gcc.20436" @default.
• W1973288013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17311253" @default.
• W1973288013 hasPublicationYear "2007" @default.
• W1973288013 type Work @default.
• W1973288013 sameAs 1973288013 @default.
• W1973288013 citedByCount "22" @default.
• W1973288013 countsByYear W19732880132013 @default.
• W1973288013 countsByYear W19732880132014 @default.
• W1973288013 countsByYear W19732880132018 @default.
• W1973288013 countsByYear W19732880132019 @default.
• W1973288013 countsByYear W19732880132020 @default.
• W1973288013 crossrefType "journal-article" @default.
• W1973288013 hasAuthorship W1973288013A5002475405 @default.
• W1973288013 hasAuthorship W1973288013A5003105021 @default.
• W1973288013 hasAuthorship W1973288013A5019711205 @default.
• W1973288013 hasAuthorship W1973288013A5044228973 @default.
• W1973288013 hasAuthorship W1973288013A5061408064 @default.
• W1973288013 hasAuthorship W1973288013A5065033706 @default.
• W1973288013 hasAuthorship W1973288013A5073907665 @default.
• W1973288013 hasAuthorship W1973288013A5077315723 @default.
• W1973288013 hasAuthorship W1973288013A5086354986 @default.
• W1973288013 hasAuthorship W1973288013A5088183144 @default.
• W1973288013 hasConcept C104317684 @default.
• W1973288013 hasConcept C126322002 @default.
• W1973288013 hasConcept C135763542 @default.
• W1973288013 hasConcept C147483822 @default.
• W1973288013 hasConcept C180754005 @default.
• W1973288013 hasConcept C188280979 @default.
• W1973288013 hasConcept C197754878 @default.
• W1973288013 hasConcept C203014093 @default.
• W1973288013 hasConcept C2779338263 @default.
• W1973288013 hasConcept C35605836 @default.
• W1973288013 hasConcept C54355233 @default.
• W1973288013 hasConcept C71924100 @default.
• W1973288013 hasConcept C84597430 @default.
• W1973288013 hasConcept C86803240 @default.
• W1973288013 hasConceptScore W1973288013C104317684 @default.
• W1973288013 hasConceptScore W1973288013C126322002 @default.
• W1973288013 hasConceptScore W1973288013C135763542 @default.
• W1973288013 hasConceptScore W1973288013C147483822 @default.
• W1973288013 hasConceptScore W1973288013C180754005 @default.
• W1973288013 hasConceptScore W1973288013C188280979 @default.
• W1973288013 hasConceptScore W1973288013C197754878 @default.
• W1973288013 hasConceptScore W1973288013C203014093 @default.
• W1973288013 hasConceptScore W1973288013C2779338263 @default.
• W1973288013 hasConceptScore W1973288013C35605836 @default.
• W1973288013 hasConceptScore W1973288013C54355233 @default.
• W1973288013 hasConceptScore W1973288013C71924100 @default.
• W1973288013 hasConceptScore W1973288013C84597430 @default.
• W1973288013 hasConceptScore W1973288013C86803240 @default.
• W1973288013 hasIssue "5" @default.
• W1973288013 hasLocation W19732880131 @default.
• W1973288013 hasLocation W19732880132 @default.
• W1973288013 hasOpenAccess W1973288013 @default.
• W1973288013 hasPrimaryLocation W19732880131 @default.

• next