Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973290209> ?p ?o ?g. }
- W1973290209 endingPage "653" @default.
- W1973290209 startingPage "629" @default.
- W1973290209 abstract "We have isolated a cDNA coding for a putative invertebrate-type dopamine receptor (Peadop2) from P. americana brain by using a PCR-based strategy. The mRNA is present in samples from brain and salivary glands. We analyzed the distribution of the PeaDOP2 receptor protein with specific affinity-purified polyclonal antibodies. On Western blots, PeaDOP2 was detected in protein samples from brain, subesophageal ganglion, thoracic ganglia, and salivary glands. In immunocytochemical experiments, we detected PeaDOP2 in neurons with their somata being located at the anterior edge of the medulla bilaterally innervating the optic lobes and projecting to the ventro-lateral protocerebrum. In order to determine the functional and pharmacological properties of the cloned receptor, we generated a cell line constitutively expressing PeaDOP2. Activation of PeaDOP2-expressing cells with dopamine induced an increase in intracellular cAMP. In contrast, a C-terminally truncated splice variant of this receptor did not exhibit any functional property by itself. The molecular and pharmacological characterization of the first dopamine receptor from P. americana provides the basis for forthcoming studies focusing on the significance of the dopaminergic system in cockroach behavior and physiology." @default.
- W1973290209 created "2016-06-24" @default.
- W1973290209 creator A5021753912 @default.
- W1973290209 creator A5043430524 @default.
- W1973290209 creator A5064634913 @default.
- W1973290209 creator A5067411991 @default.
- W1973290209 creator A5079455167 @default.
- W1973290209 date "2014-01-06" @default.
- W1973290209 modified "2023-10-18" @default.
- W1973290209 title "Characterization of an Invertebrate-Type Dopamine Receptor of the American Cockroach, Periplaneta americana" @default.
- W1973290209 cites W1518293453 @default.
- W1973290209 cites W1559175225 @default.
- W1973290209 cites W1567740502 @default.
- W1973290209 cites W1605906079 @default.
- W1973290209 cites W1614960091 @default.
- W1973290209 cites W1689798268 @default.
- W1973290209 cites W1718945950 @default.
- W1973290209 cites W1833104430 @default.
- W1973290209 cites W1835233110 @default.
- W1973290209 cites W1849896091 @default.
- W1973290209 cites W1925492557 @default.
- W1973290209 cites W1934371372 @default.
- W1973290209 cites W1954929088 @default.
- W1973290209 cites W1964315553 @default.
- W1973290209 cites W1965111478 @default.
- W1973290209 cites W1966020275 @default.
- W1973290209 cites W1966458871 @default.
- W1973290209 cites W1966699968 @default.
- W1973290209 cites W1966840888 @default.
- W1973290209 cites W1967004438 @default.
- W1973290209 cites W1967504213 @default.
- W1973290209 cites W1968164772 @default.
- W1973290209 cites W1971147414 @default.
- W1973290209 cites W1973756587 @default.
- W1973290209 cites W1974447470 @default.
- W1973290209 cites W1976699061 @default.
- W1973290209 cites W1977761627 @default.
- W1973290209 cites W1978310995 @default.
- W1973290209 cites W1979224892 @default.
- W1973290209 cites W1982449267 @default.
- W1973290209 cites W1991757737 @default.
- W1973290209 cites W1991955609 @default.
- W1973290209 cites W1993677150 @default.
- W1973290209 cites W1997218457 @default.
- W1973290209 cites W1999651842 @default.
- W1973290209 cites W1999992568 @default.
- W1973290209 cites W2000957361 @default.
- W1973290209 cites W2002342657 @default.
- W1973290209 cites W2007499400 @default.
- W1973290209 cites W2008968520 @default.
- W1973290209 cites W2017213666 @default.
- W1973290209 cites W2019572822 @default.
- W1973290209 cites W2020149357 @default.
- W1973290209 cites W2030252204 @default.
- W1973290209 cites W2031236088 @default.
- W1973290209 cites W2031605595 @default.
- W1973290209 cites W2033099086 @default.
- W1973290209 cites W2039722354 @default.
- W1973290209 cites W2043240702 @default.
- W1973290209 cites W2049781145 @default.
- W1973290209 cites W2052117838 @default.
- W1973290209 cites W2052469571 @default.
- W1973290209 cites W2054740489 @default.
- W1973290209 cites W2061148723 @default.
- W1973290209 cites W2062239193 @default.
- W1973290209 cites W2064372048 @default.
- W1973290209 cites W2064959156 @default.
- W1973290209 cites W2065240767 @default.
- W1973290209 cites W2067013531 @default.
- W1973290209 cites W2070405413 @default.
- W1973290209 cites W2071728323 @default.
- W1973290209 cites W2072633855 @default.
- W1973290209 cites W2074622376 @default.
- W1973290209 cites W2076563355 @default.
- W1973290209 cites W2076976482 @default.
- W1973290209 cites W2077251026 @default.
- W1973290209 cites W2079625239 @default.
- W1973290209 cites W2082551067 @default.
- W1973290209 cites W2082651629 @default.
- W1973290209 cites W2083210106 @default.
- W1973290209 cites W2083342137 @default.
- W1973290209 cites W2085462740 @default.
- W1973290209 cites W2086880198 @default.
- W1973290209 cites W2090267487 @default.
- W1973290209 cites W2092148890 @default.
- W1973290209 cites W2092212345 @default.
- W1973290209 cites W2097056699 @default.
- W1973290209 cites W2102791000 @default.
- W1973290209 cites W2108762933 @default.
- W1973290209 cites W2109227456 @default.
- W1973290209 cites W2111161359 @default.
- W1973290209 cites W2112212749 @default.
- W1973290209 cites W2113638222 @default.
- W1973290209 cites W2117012243 @default.
- W1973290209 cites W2117869099 @default.
- W1973290209 cites W2122241458 @default.
- W1973290209 cites W2122669559 @default.
- W1973290209 cites W2124021890 @default.