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- W1973291268 abstract "In recent years, the interest in nanostructured systems to drug delivery has increased because they offer several advantages over conventional dosage forms. Solid Lipid Nanoparticles (SLN) have been highlighted among these systems because they have advantages such as high physical stability, protection against drug degradation and ease of scale-up and manufacturing, without using organic solvent. The aim of this work was to evaluate the potential of SLN, by in vitro cytotoxicity assays, for dermal drug delivery. SLN of three different lipids were prepared by hot high pressure homogenization and the cytotoxicity was assessed by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyl tetrazolium bromide (MTT) test in mouse 3T3 fibroblasts and human HaCaT keratinocytes. SLN showed no cytotoxic potential suggesting a great potential for dermal application." @default.
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- W1973291268 date "2011-07-06" @default.
- W1973291268 modified "2023-10-16" @default.
- W1973291268 title "In vitro cytotoxicity assays of solid lipid nanoparticles in epithelial and dermal cells" @default.
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- W1973291268 doi "https://doi.org/10.1088/1742-6596/304/1/012032" @default.
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