Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973291424> ?p ?o ?g. }
- W1973291424 endingPage "406" @default.
- W1973291424 startingPage "397" @default.
- W1973291424 abstract "The endocrine hormone, 1α,25-dihydroxyvitamin D3 (1,25D) is an important regulator of calcium and phosphorus homeostasis. In this context, 1,25D is generally recognized as necessary for the maintenance of a healthy skeleton through its actions on the small intestine. In this review, we highlight the direct effects of 1,25D on the constituent cells of the bone, actions that are independent of effects on the intestine and kidney. We also consider the evidence that 25D levels, not 1,25D levels, correlate best with parameters of bone health, and that the bone itself is a site of metabolic conversion of 25D into 1,25D, by virtue of its expression of the 25-hydroxyvitamin D 1α-hydroxylase, CYP27B1. We review the evidence that at least osteoblasts and chondrocytes, and possibly also bone resorbing osteoclasts, are capable of such metabolic conversion, and therefore that these cells likely participate in autocrine and paracrine loops of vitamin D metabolism. We conclude that the skeleton is an intracrine organ for vitamin D metabolism, challenging the long-held notion that 1,25D is solely an endocrine hormone." @default.
- W1973291424 created "2016-06-24" @default.
- W1973291424 creator A5023571108 @default.
- W1973291424 creator A5051520123 @default.
- W1973291424 date "2008-12-01" @default.
- W1973291424 modified "2023-09-27" @default.
- W1973291424 title "The skeleton as an intracrine organ for vitamin D metabolism" @default.
- W1973291424 cites W14434390 @default.
- W1973291424 cites W1486598646 @default.
- W1973291424 cites W1490687264 @default.
- W1973291424 cites W1534645474 @default.
- W1973291424 cites W1543525745 @default.
- W1973291424 cites W1623258939 @default.
- W1973291424 cites W1663317712 @default.
- W1973291424 cites W1964234958 @default.
- W1973291424 cites W1964306502 @default.
- W1973291424 cites W1967380126 @default.
- W1973291424 cites W1969065492 @default.
- W1973291424 cites W1971755627 @default.
- W1973291424 cites W1972216923 @default.
- W1973291424 cites W1974534962 @default.
- W1973291424 cites W1978055743 @default.
- W1973291424 cites W1979612958 @default.
- W1973291424 cites W1984821835 @default.
- W1973291424 cites W1984903049 @default.
- W1973291424 cites W1989700145 @default.
- W1973291424 cites W1990935283 @default.
- W1973291424 cites W1994960039 @default.
- W1973291424 cites W1997581290 @default.
- W1973291424 cites W1999237472 @default.
- W1973291424 cites W2000647744 @default.
- W1973291424 cites W2001417250 @default.
- W1973291424 cites W2004671961 @default.
- W1973291424 cites W2010616783 @default.
- W1973291424 cites W2011082454 @default.
- W1973291424 cites W2014881074 @default.
- W1973291424 cites W2017231491 @default.
- W1973291424 cites W2017290177 @default.
- W1973291424 cites W2018809127 @default.
- W1973291424 cites W2021857647 @default.
- W1973291424 cites W2024160556 @default.
- W1973291424 cites W2027363930 @default.
- W1973291424 cites W2028927099 @default.
- W1973291424 cites W2032330514 @default.
- W1973291424 cites W2032994380 @default.
- W1973291424 cites W2040730084 @default.
- W1973291424 cites W2042432961 @default.
- W1973291424 cites W2046340099 @default.
- W1973291424 cites W2046473453 @default.
- W1973291424 cites W2049392332 @default.
- W1973291424 cites W2049454211 @default.
- W1973291424 cites W2050589911 @default.
- W1973291424 cites W2051959338 @default.
- W1973291424 cites W2055730405 @default.
- W1973291424 cites W2056116219 @default.
- W1973291424 cites W2060331245 @default.
- W1973291424 cites W2062361583 @default.
- W1973291424 cites W2062709100 @default.
- W1973291424 cites W2064714960 @default.
- W1973291424 cites W2066884044 @default.
- W1973291424 cites W2069410160 @default.
- W1973291424 cites W2069979659 @default.
- W1973291424 cites W2071680917 @default.
- W1973291424 cites W2072256043 @default.
- W1973291424 cites W2072917762 @default.
- W1973291424 cites W2073406262 @default.
- W1973291424 cites W2077344034 @default.
- W1973291424 cites W2087333134 @default.
- W1973291424 cites W2094048780 @default.
- W1973291424 cites W2097191932 @default.
- W1973291424 cites W2097743908 @default.
- W1973291424 cites W2101422590 @default.
- W1973291424 cites W2109608328 @default.
- W1973291424 cites W2110690276 @default.
- W1973291424 cites W2115155753 @default.
- W1973291424 cites W2115454272 @default.
- W1973291424 cites W2126517599 @default.
- W1973291424 cites W2128843508 @default.
- W1973291424 cites W2129812644 @default.
- W1973291424 cites W2134476490 @default.
- W1973291424 cites W2139996507 @default.
- W1973291424 cites W2146640173 @default.
- W1973291424 cites W2147428009 @default.
- W1973291424 cites W2147832664 @default.
- W1973291424 cites W2148529881 @default.
- W1973291424 cites W2149949422 @default.
- W1973291424 cites W2153149830 @default.
- W1973291424 cites W2159877829 @default.
- W1973291424 cites W2161111422 @default.
- W1973291424 cites W2161824703 @default.
- W1973291424 cites W2168187262 @default.
- W1973291424 cites W2169970337 @default.
- W1973291424 cites W2314110838 @default.
- W1973291424 cites W2335931427 @default.
- W1973291424 cites W4245958271 @default.
- W1973291424 cites W4293658652 @default.
- W1973291424 cites W4317707791 @default.
- W1973291424 cites W55700635 @default.