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• W1973292232 startingPage "404" @default.
• W1973292232 abstract "Advances in gene transfer to the conducting airways for the treatment of pulmonary diseases such as cystic fibrosis have identified several vector classes that transduce airway epithelia in vitro and in animal models. One barrier to epithelial gene transfer is the rapid removal of materials from the airway surface via mucociliary clearance. This host defense mechanism limits gene transfer efficiency to airway epithelial cells. Here we show that formulation of gene transfer vectors with viscoelastic gels provides longer epithelial residence time and increases vector-mediated gene transfer efficiency. Gene transfer with adenoviral, adeno-associated, and lentiviral vectors all significantly improved after formulation with viscoelastic gels designed to slow mucociliary clearance. Importantly, viscoelastic gel formulations enhanced vector transduction to the conducting airways, the desired treatment target for diseases such as cystic fibrosis." @default.
• W1973292232 created "2016-06-24" @default.
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• W1973292232 date "2005-05-01" @default.
• W1973292232 modified "2023-09-27" @default.
• W1973292232 title "Viscoelastic Gel Formulations Enhance Airway Epithelial Gene Transfer with Viral Vectors" @default.
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• W1973292232 doi "https://doi.org/10.1165/rcmb.2004-0410oc" @default.
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• W1973292232 hasPublicationYear "2005" @default.
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