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- W1973294295 endingPage "217" @default.
- W1973294295 startingPage "207" @default.
- W1973294295 abstract "Tumor cell survival is highly dependent on the expression of certain pro-survival Bcl-2 family proteins. An attractive therapeutic approach is to inhibit these proteins using agents that mimic the Bcl-2 homology 3 (BH3) domains of the proapoptotic Bcl-2 family members, which neutralize these proteins by binding to their surface hydrophobic grooves. A number of BH3 mimetic peptides and small molecules have been described, a few of which have advanced into clinical trials. Recent studies have highlighted ABT-737, a bona fide BH3 mimetic and potent inhibitor of antiapoptotic Bcl-2 family members, as a promising anticancer agent. This review summarizes recent advances in understanding the mechanisms of action of BH3 domains and several classes of BH3 mimetics, as well as the prospects of using these agents to improve cancer therapy." @default.
- W1973294295 created "2016-06-24" @default.
- W1973294295 creator A5019759735 @default.
- W1973294295 creator A5028963094 @default.
- W1973294295 creator A5086910766 @default.
- W1973294295 date "2007-12-01" @default.
- W1973294295 modified "2023-09-25" @default.
- W1973294295 title "BH3 mimetics to improve cancer therapy; mechanisms and examples" @default.
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