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- W1973294975 abstract "Polyketide derivatives, such as 1, are obtained in enhanced yield from added benzoate by coexpressing in Saccharopolyspora erythraea a hybrid erythromycin–soraphen polyketide synthase (PKS) together with benzoate:CoA ligase from the enterocin-producing (enc) pathway of a marine streptomycete. Remarkably, coexpression of the single gene encP encoding phenylalanine ammonia lyase is sufficient to produce the PKS primer benzoyl-CoA in S. erythraea from endogenous L-phenylalanine without any need to supply precursors in the medium." @default.
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- W1973294975 date "2004-08-02" @default.
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- W1973294975 title "Engineered Biosynthesis of Phenyl-Substituted Polyketides" @default.
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- W1973294975 doi "https://doi.org/10.1002/cbic.200400007" @default.
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