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• W1973296424 abstract "Compound 7 was identified as the active metabolite of 6 by HPLC and mass spectral analysis. Modification of lead compound 7 by transformation of its N-oxide 6–6 biaryl ring system and fused aromatics produced a series of non-basic fXa inhibitors with excellent potency in anti-fXa and anticoagulant assays. The optimized compounds 73b and 75b showed sub to one digit micromolar anticoagulant activity (PTCT2). Particularly, anti-fXa activity was detected in plasma of rats orally administered with 1 mg/kg of compound 75b." @default.
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• W1973296424 date "2005-06-01" @default.
• W1973296424 modified "2023-09-23" @default.
• W1973296424 title "Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites" @default.
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• W1973296424 doi "https://doi.org/10.1016/j.bmc.2005.04.006" @default.
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