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• W1973296637 abstract "An expression of the surface co-stimulatory molecules-the CD152 and the CD28 has been compared between young and old individuals on the CD8(high+) lymphocytes. Sixty five elderly healthy (65-96 years old) and 31 young (19-40 years old) volunteers were examined. An expression of CD152 and CD28 surface antigens was analyzed by flow cytometry ex vivo and on whole blood cell cultures lymphocytes stimulated with interleukin 2 (IL2). The elderly population was characterized by a lower percentage of the CD8(high+) lymphocytes than the young population. The percentages of CD28(+) lymphocytes as well as those of CD8(high+)CD28(+) subpopulation were lower in the old group compared to the young group. The surface expression of CD152 antigen was similar to that of CD28 with a lower percentage of the CD152(+) lymphocytes and CD8(high+)CD152(+) cells in the old group. Stimulation of lymphocytes in vitro with IL2 resulted in an increase of the CD8(high+)CD152(+) cells in the elderly, while it had no effect on lymphocytes of the young group. Our results indicate that lymphocytes of the elderly population are characterized by a lower expression of the surface CD28 and CD152 molecules. An age-related decrease of an expression of the co-stimulatory molecules CD28 and CD152 on the surface of lymphocytes, found in our study, may be compatible with a hypothesis of a 'remodelling' of immune response in the healthy elderly." @default.
• W1973296637 created "2016-06-24" @default.
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• W1973296637 date "2002-05-01" @default.
• W1973296637 modified "2023-09-27" @default.
• W1973296637 title "Lower percentage of CD8high+CD152+ but not CD8high+CD28+ T lymphocytes in the elderly may be reverted by interleukin 2 in vitro" @default.
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• W1973296637 doi "https://doi.org/10.1016/s0047-6374(02)00016-7" @default.
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