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- W1973319971 abstract "Various neurodegenerative diseases are characterized by aggregates of pathological proteins, and increasing evidence suggests these disease-associated proteins may 'spread' via neuronal connections. Trojanowski and colleagues describe the molecular mechanisms of such spreading, and present the findings from neuropathological and imaging studies in humans that support this process. The progression of many neurodegenerative diseases is thought to be driven by the template-directed misfolding, seeded aggregation and cell–cell transmission of characteristic disease-related proteins, leading to the sequential dissemination of pathological protein aggregates. Recent evidence strongly suggests that the anatomical connections made by neurons — in addition to the intrinsic characteristics of neurons, such as morphology and gene expression profile — determine whether they are vulnerable to degeneration in these disorders. Notably, this common pathogenic principle opens up opportunities for pursuing novel targets for therapeutic interventions for these neurodegenerative disorders. We review recent evidence that supports the notion of neuron–neuron protein propagation, with a focus on neuropathological and positron emission tomography imaging studies in humans." @default.
- W1973319971 created "2016-06-24" @default.
- W1973319971 creator A5005516568 @default.
- W1973319971 creator A5021394368 @default.
- W1973319971 creator A5049320398 @default.
- W1973319971 creator A5065852445 @default.
- W1973319971 date "2015-01-15" @default.
- W1973319971 modified "2023-10-18" @default.
- W1973319971 title "Spreading of pathology in neurodegenerative diseases: a focus on human studies" @default.
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