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• W1973350635 abstract "The effects of various types of inducing agents on the hepatic microsomal monooxygenase (MO) system of rainbow trout were examined and compared to the induction profiles observed following pretreatment with either 3-methylcholanthrene- or phenobarbital-type inducers. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) elevated ethoxycoumarin- and ethoxyresorufin-O-deethylase activities (ECOD, EROD) as well as the cytochrome(s) P-450 content, but had no effect on benzphetamine-N-demethylation (BeND). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of solubilized microsomes from TCDD-pretreated fish demonstrated the intensification of a protein band with a molecular weight of 57,000. Although the magnitude of induction was not as great, isosafrole pretreatment of rainbow trout resulted in an induction profile similar to that observed following TCDD administration to these animals. Neither Kepone nor mirex had a stimulatory effect on any of the measured parameters and neither caused a change in the protein profile following SDS-PAGE of solubilized microsomes. These results suggest that fish respond differently from mammals to these inducers of the hepatic microsomal MO system." @default.
• W1973350635 created "2016-06-24" @default.
• W1973350635 creator A5034637776 @default.
• W1973350635 creator A5077301656 @default.
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• W1973350635 date "1981-06-01" @default.
• W1973350635 modified "2023-09-26" @default.
• W1973350635 title "The effect of various types of inducing agents on hepatic microsomal monooxygenase activity in rainbow trout" @default.
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• W1973350635 doi "https://doi.org/10.1016/0041-008x(81)90208-8" @default.
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