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- W1973352832 endingPage "316" @default.
- W1973352832 startingPage "304" @default.
- W1973352832 abstract "Worldwide obesity is a growing health problem, associated with increased risk of chronic disease. Understanding the molecular basis of adipogenesis and fat cell development in obesity is essential to identify new biomarkers and therapeutic targets for the development of anti-obesity drugs. microRNAs (miRNAs) appear to play regulatory roles in many biological processes associated with obesity, including adipocyte differentiation, insulin action and fat metabolism. Recent studies show miRNAs are dysregulated in obese adipose tissue. During adipogenesis miRNAs can accelerate or inhibit adipocyte differentiation and hence regulate fat cell development. In addition miRNAs may regulate adipogenic lineage commitment in multipotent stem cells and hence govern fat cell numbers. Recent findings suggest miR-519d may be associated with human obesity, but larger case-control studies are needed. Few miRNA targets have been experimentally validated in adipocytes but interestingly both miR-27 and miR-519d target PPAR family members, which are well established regulators of fat cell development. In this review recent advances in our understanding of the role of miRNAs in fat cell development and obesity are discussed. The potential of miRNA based therapeutics targeting obesity is highlighted as well as recommendations for future research which could lead to a breakthrough in the treatment of obesity. Keywords: Adipocytes, adipogenesis, biomarkers, microRNAs, miR-27, miR-519d, obesity, chronic diseases, therapeutic targets, adipogenic differentiation, adipocyte biology, biogenesis, inflammatory cytokines, anti-obesity treatments, apoptosis" @default.
- W1973352832 created "2016-06-24" @default.
- W1973352832 creator A5030500129 @default.
- W1973352832 creator A5031004025 @default.
- W1973352832 date "2011-06-01" @default.
- W1973352832 modified "2023-10-11" @default.
- W1973352832 title "microRNAs in the Regulation of Adipogenesis and Obesity" @default.
- W1973352832 cites W1489925379 @default.
- W1973352832 cites W1520671195 @default.
- W1973352832 cites W1631449371 @default.
- W1973352832 cites W1965079305 @default.
- W1973352832 cites W1969104747 @default.
- W1973352832 cites W1971680163 @default.
- W1973352832 cites W1975072242 @default.
- W1973352832 cites W1975701450 @default.
- W1973352832 cites W1975998449 @default.
- W1973352832 cites W1978337436 @default.
- W1973352832 cites W1980269624 @default.
- W1973352832 cites W1981332939 @default.
- W1973352832 cites W1981670717 @default.
- W1973352832 cites W1982844521 @default.
- W1973352832 cites W1983251404 @default.
- W1973352832 cites W1985140771 @default.
- W1973352832 cites W1986903527 @default.
- W1973352832 cites W1987248329 @default.
- W1973352832 cites W1988163167 @default.
- W1973352832 cites W1989020172 @default.
- W1973352832 cites W1992084001 @default.
- W1973352832 cites W1992935306 @default.
- W1973352832 cites W1994192201 @default.
- W1973352832 cites W1994645662 @default.
- W1973352832 cites W1997296994 @default.
- W1973352832 cites W1997386949 @default.
- W1973352832 cites W2000496185 @default.
- W1973352832 cites W2001290163 @default.
- W1973352832 cites W2002341492 @default.
- W1973352832 cites W2005827500 @default.
- W1973352832 cites W2011543211 @default.
- W1973352832 cites W2012037560 @default.
- W1973352832 cites W2025211905 @default.
- W1973352832 cites W2026570544 @default.
- W1973352832 cites W2027862889 @default.
- W1973352832 cites W2031014255 @default.
- W1973352832 cites W2033374739 @default.
- W1973352832 cites W2040191060 @default.
- W1973352832 cites W2042673698 @default.
- W1973352832 cites W2045672814 @default.
- W1973352832 cites W2045913350 @default.
- W1973352832 cites W2047254315 @default.
- W1973352832 cites W2047413348 @default.
- W1973352832 cites W2048135758 @default.
- W1973352832 cites W2050869737 @default.
- W1973352832 cites W2052098392 @default.
- W1973352832 cites W2054109341 @default.
- W1973352832 cites W2059357290 @default.
- W1973352832 cites W2059992589 @default.
- W1973352832 cites W2060141541 @default.
- W1973352832 cites W2060374902 @default.
- W1973352832 cites W2060978273 @default.
- W1973352832 cites W2061829501 @default.
- W1973352832 cites W2065566217 @default.
- W1973352832 cites W2067961704 @default.
- W1973352832 cites W2070172494 @default.
- W1973352832 cites W2070207988 @default.
- W1973352832 cites W2076414052 @default.
- W1973352832 cites W2077114801 @default.
- W1973352832 cites W2079248832 @default.
- W1973352832 cites W2083381199 @default.
- W1973352832 cites W2088648948 @default.
- W1973352832 cites W2089001345 @default.
- W1973352832 cites W2090219560 @default.
- W1973352832 cites W2098285533 @default.
- W1973352832 cites W2098390372 @default.
- W1973352832 cites W2104827888 @default.
- W1973352832 cites W2107961632 @default.
- W1973352832 cites W2109481604 @default.
- W1973352832 cites W2110270688 @default.
- W1973352832 cites W2115093090 @default.
- W1973352832 cites W2117555254 @default.
- W1973352832 cites W2118105142 @default.
- W1973352832 cites W2119043140 @default.
- W1973352832 cites W2130979840 @default.
- W1973352832 cites W2131525837 @default.
- W1973352832 cites W2134384157 @default.
- W1973352832 cites W2142310248 @default.
- W1973352832 cites W2143168180 @default.
- W1973352832 cites W2143355329 @default.
- W1973352832 cites W2146278947 @default.
- W1973352832 cites W2147071298 @default.
- W1973352832 cites W2149127304 @default.
- W1973352832 cites W2149291473 @default.
- W1973352832 cites W2151115776 @default.
- W1973352832 cites W2151922790 @default.
- W1973352832 cites W2152083180 @default.
- W1973352832 cites W2159999899 @default.
- W1973352832 cites W2161068194 @default.
- W1973352832 cites W2161222316 @default.
- W1973352832 cites W2161693225 @default.