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- W1973364953 abstract "Cell-type specific expression of the human diphtheria toxin receptor in generally toxin resistant mice represents an innovative approach for the selective depletion of pre-defined cell populations. We demonstrate that in wildtype mice diphtheria toxin--in concentrations otherwise well tolerated--is highly toxic and lethal together with active immunization irrespective of the immunogenic peptide applied. We found increased lung cellularity as only pathological abnormality. Animal models of inflammatory diseases requiring active immunization including experimental autoimmune encephalomyelitis may thus not be applicable in diphtheria receptor transgenic mice pointing to a major limitation of this otherwise technically interesting approach." @default.
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- W1973364953 date "2010-03-01" @default.
- W1973364953 modified "2023-09-27" @default.
- W1973364953 title "Active immunization induces toxicity of diphtheria toxin in diphtheria resistant mice — Implications for neuroinflammatory models" @default.
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- W1973364953 doi "https://doi.org/10.1016/j.jim.2010.01.012" @default.
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