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- W1973365874 abstract "Abstract Acute graft-versus-host disease (aGVHD) impairs thymus-dependent T-cell regeneration in recipients of allogeneic bone marrow transplants through yet to be defined mechanisms. Here, we demonstrate in mice that MHC-mismatched donor T cells home into the thymus of unconditioned recipients. There, activated donor T cells secrete IFN-γ, which in turn stimulates the programmed cell death of thymic epithelial cells (TECs). Because TECs themselves are competent and sufficient to prime naive allospecific T cells and to elicit their effector function, the elimination of host-type professional antigen-presenting cells (APCs) does not prevent donor T-cell activation and TEC apoptosis, thus precluding normal thymopoiesis in transplant recipients. Hence, strategies that protect TECs may be necessary to improve immune reconstitution following allogeneic bone marrow transplantation." @default.
- W1973365874 created "2016-06-24" @default.
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- W1973365874 date "2007-01-09" @default.
- W1973365874 modified "2023-10-16" @default.
- W1973365874 title "Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation" @default.
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- W1973365874 doi "https://doi.org/10.1182/blood-2006-07-034157" @default.
- W1973365874 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1874583" @default.
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