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- W1973366381 abstract "In Saccharomyces cerevisiae, the cell integrity pathway plays a role in the oxidative stress response. In this study, we show that the Pkc1 protein mediates oxidative signalling by helping to downregulate ribosomal gene expression when cells are exposed to hydrogen peroxide. An active actin cytoskeleton is required for this function, because the cells blocked in actin polymerisation were unable to repress ribosomal gene transcription. Following the invertase secretion pattern, we hypothesize that oxidative stress induced by hydrogen peroxide could have affected the latter steps of secretion. This would explain why the Pkc1 function was required to repress ribosomal biogenesis." @default.
- W1973366381 created "2016-06-24" @default.
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- W1973366381 date "2011-09-27" @default.
- W1973366381 modified "2023-10-05" @default.
- W1973366381 title "Pkc1 and actin polymerisation activities play a role in ribosomal gene repression associated with secretion impairment caused by oxidative stress" @default.
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- W1973366381 doi "https://doi.org/10.1111/j.1567-1364.2011.00754.x" @default.
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